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Mothering › Health Articles › Genetics And Detoxification

Genetics And Detoxification

Based on the guessing your genetics thread in allergies

 

When a human body has something that it doesn't want, be it a used hormone, metabolic waste like ammonia, things like salicylates from food, or a chemical from the environment like antimony in flame retardants or mercury in fillings, it has ways to dispose of the toxin.  Enzymes in the body process the toxin, flag it for excretion, and excrete it.  There is a ton of individual variability in that process, and a lot of it comes down to genetics.  For those of us who are interested in genetic testing, hopefully this wiki will make some sense of the alphabet soup and provide some clues for how we can feel better.

 

The two tests are Dr Amy Yasko's Nutrigenomic Profile and 23andMe's Genetic Testing.  Both test SNPs, single nucleotide polymorphisms.  In Yasko-speak, a '-' means you have the 'normal' genetic variant, while a '+' means you may have issues with that enzyme.  So, if you're COMT ++ or +/- you'd want to pay special attention to COMT symptoms and supports, while if you're COMT --, you'd likely be better off focusing your attention elsewhere.  

 

To make things good and confusing, 23andMe uses a different standard for naming the SNPs, AND sometimes they're looking at the mirror image of the DNA, so the letters may be completely different.  In the table below, we've done our best at translating Yasko speak into 23andMe speak.  So if you're looking at the first row, COMT V158M, on your Yasko results a G means you're COMT --.  If you click on the 23andMe name, look at the two letters on the right side of the line once you're logged in, and compare to the last column in this table below.  The (plus) or (minus) has to do with which part of the DNA strand 23andMe is looking at.  Ignore it for now.  If you see a GG on your results, that means you're COMT--. 

 

 

Gene

Yasko

Name

Yasko

normal

23andMe

Name

23andMe

normal

COMT V158M G(-) rs4680 G (plus)
COMT H62H C(-) rs4633 C (plus)
COMT 61 G(-) rs769224 G (plus)
VDR Taq T(+) (rs731236)  
VDR Fok   rs10735810  (plus)
MAO-A R297R G(-) T(+) rs6323 G (plus)
ACAT 1-02 A(+)    
ACE Del16 I(-) rs1799752 I (plus)
MTHFR C677T

C(-) T(+)

rs1801133  G (minus)
MTHFR 3 C(-)    
MTHFR A1298C A(-) rs1801131  T (minus)
MTR  A2756G  A(-) rs1805087  A (plus)
MTRR  A66G  A(-) rs1801394  A (plus)
MTRR  H595Y  C(-) rs10380  C (plus)
MTRR  K350A  A(-) rs162036? A (plus)
MTRR  R415T  C(-) rs2287780? C (plus)
MTRR  S257T  T(-) (rs2303080)  
MTRR  11  G(-)    
BHMT  1 (-) rs492842?  (minus)
BHMT  2 C(-) rs6894156? C (plus)
BHMT  4 (-)

rs6875201 or

rs379754

(plus)

 

BHMT  8 T(+)

rs3797546 or

rs567754

 (plus)

 (plus)

AHCY  1 A(-)    
AHCY  2 T(-) rs1205357  (plus)
AHCY  19 A(-)    
CBS  C699T  C(-) rs234706   (plus)
CBS  A360A  C(-) T(+) (rs1801181)  
SUOX  S370S (-)    
SHMT  C1420T  G(-) (rs1979277)  
NOS  D298E  (-) rs1799983  (plus)
         

 

Now that you have a list of which genes to focus on, let's move on to what to do about them.  Yasko's book is on google books, which gives a rundown of each mutation.  Heartfixer has a summary of each gene and how to address it as well.  These two are the source of most of the information in the next table.

 

Gene

Short

Description

Symptoms

to Watch

How to

Address

Comments
COMT

Catechol-O-methyltransferase

Affects how fast or slow you use methyl groups.  COMT++ means you 

Dopamine levels (blink rates) Avoid methyl donors This one can hide and look like COMT-- until other supports are in place.

VDR

Taq

Vitamin D Receptor Taq

 

     

VDR

Fok

       
MAO-A

Monoamine oxidase

Affects how quickly you break down amines.

Serotonin swings and needing quiet time quiet time Carried on the X chromosome, so boys just have one copy from mom.
ACAT        
ACE        

MTHFR 

C677T

  homocysteine, methylation folate  

MTHFR 

A1298C

  low neurotransmitters/ moodiness, high ammonia folate  
MTR     B12  
MTRR     B12  
BHMT        
ACHY        
CBS     watch protein  
SUOX     Mo, B6  
SHMT        
NOS   high ammonia, oxidative stress    
         
         
         

 

Comments (1)

Very nice! Comprehensive and very helpful fro someone trying to find specific issues with a doc who seems clueless.
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