Well, yes and no, heathergirl.
For example, polio was floating around for thousands of years. But paralytic polio was not. It is a disease of modernity.
Mumps keeps popping up, in spite of the vaccine. Unfortunately, it is popping up in teens and young adults, where it is a much more dangerous and painful illness.
Pertussis, as has been widely discussed on this board, circulates like mad, despite the vaccine.
Hib and Prevnar both create issues of serotype replacement,...