We relocated from San Antonio TX to Denver about 3 years ago. We sold our house in just 3 days and my husband was able to transfer with his company. In fact we've survived a few major moves. If you want to do it, go for it, it'll work out if it's meant to be.
We moved for similar reasons, all of our family is in Colorado and we wanted a change. San Antonio was cool in it's own way but just not for us long term.