i have very rashy babies. If they sit in diapers 24/7, they're going to get red sores on their butts that eventually blister and look like chemical burns.
It took me four infants to realize that no amount of chemical goo, salves, special detergents etc. is going to change that: my kids will always need breatheable diaper covers, lots of changes, and nekkie-butt time.
this one is ec'd imperfectly but the big difference is that he sleeps on the washable cloth underpads (like chux) that i bought for his birth.
i use plain prefolds without fleece. i want us to know when he is wet so i can change the dipe asap.
i use plain water on his skin. no soap, no lotion, no fragrance, no nothing. i rarely wash his butt after a pee diaper, but i do try to let it air out for at least 5 minutes before rediapering him if i can.
so far, he is doing SPECTACULARLY compared to his sibs, but it only took one spur-of-the-moment sleepover with friends who were too far past the diapering stage for me to ask for towels or other makeshift nekkid baby hygeine materials for me to see that familiar rash starting on him too.
So in my rather extensive experience, air is more effective than water in preventing pee rashes.