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detox pathway guinea pig - Page 15

post #281 of 829
Thread Starter 
Quote:
Originally Posted by chlobo View Post
This is interesting. I still can't figure out my pathway stuff. However, I do have fatigued adrenals. I believe my cholesterol is low (going to have a retest soon) and I've always craved carbs big time. I do love chocolate too. Once I start eating it I can't stop. Maybe this might do something for me.
Can you point to a time when the adrenal fatigue started? I think I was in resistance phase pretty much my whole life... And coA deficiency stimulates the adrenals...

Acetyl coA is the first building block for cholesterol.

Carb cravings are linked to low serotonin. Is depression an issue for you?

Chocolate cravings are linked to magnesium deficiency, which is needed to create coA (and cysteine).
post #282 of 829
Quote:
Originally Posted by whoMe View Post
Can you point to a time when the adrenal fatigue started? I think I was in resistance phase pretty much my whole life... And coA deficiency stimulates the adrenals...

Acetyl coA is the first building block for cholesterol.

Carb cravings are linked to low serotonin. Is depression an issue for you?

Chocolate cravings are linked to magnesium deficiency, which is needed to create coA (and cysteine).
I think I've been working on it for a good long while. I've had really low cholesterol for a long time. I thought it was good before. I've always craved carbs. I've had depression issues for years. Since I was in my teens. Nothing debilitating. Just not very happy. Now, I don't feel "as depressed". I just feel tired and frustrated at being tired. I've also had "anger" issues for years now. I'd say since my 20s. But its been really bad since my daughter was born 5 years ago.
post #283 of 829
Quote:
Originally Posted by whoMe View Post
I was going to ask... Where do you think I got the lead?
I'm glad you followed it.
I was dreaming about glutathione, vitamins, methionine and purines last night, btw. I was literally chasing them around in my dreams down their little pathways... No wonder I'm tired today!

ETA: I remember at one point in the dream saying "Oh no! It's an MTHF trap!!" when I came to a dead-end. :
post #284 of 829
I'm just so amazingly impressed with you ladies. How do you figure this all out and remember it? I can hardly remember my name lately.

You guys are da bomb!
post #285 of 829
Thread Starter 
Quote:
Originally Posted by JacquelineR View Post
I'm glad you followed it.
I was dreaming about glutathione, vitamins, methionine and purines last night, btw. I was literally chasing them around in my dreams down their little pathways... No wonder I'm tired today!

ETA: I remember at one point in the dream saying "Oh no! It's an MTHF trap!!" when I came to a dead-end.
I must have been channeling the thoughts to you cause I was up all night thinking about it. (Couldn't sleep so was thinking about it, not that it was keeping me up.. )

Jacqueline and everyone else, you've been critical in me figuring this out, whether with actual information or just feeding me energy. THANK YOU!
post #286 of 829
Quote:
Originally Posted by whoMe View Post
did you see eatingcultures for a place to start?

glutathione -

Food glutathione is absorbed well, supplements are not. If you need to supplement, cystine seems the way to go. It's one of the three amino acids glutathione is made up of.

What I'm talking about doing here is supplementing cystine for the sake of making coA out of my B5. A happy side effect is that my (apparently non-operating) glutathione pathway will suddenly open up. My main supplements are going to be B5+NAC (for coA - adrenals, cholesterol, and glutathione), folate (for BH4, and methyl groups) and stick to minimum high quality protein (to minimize ammonia). Hopefully doing this will completely perk up my adrenals, ramp up cholesterol production, and improve detox. And I have hopes it will get me off of the other vitamins and kill the chocolate and carb cravings! All from one magic little pill. Wouldn't that be something?
Quote:
Originally Posted by whoMe View Post
Can you point to a time when the adrenal fatigue started? I think I was in resistance phase pretty much my whole life... And coA deficiency stimulates the adrenals...

Acetyl coA is the first building block for cholesterol.

Carb cravings are linked to low serotonin. Is depression an issue for you?

Chocolate cravings are linked to magnesium deficiency, which is needed to create coA (and cysteine).
Quote:
Originally Posted by chlobo View Post
I think I've been working on it for a good long while. I've had really low cholesterol for a long time. I thought it was good before. I've always craved carbs. I've had depression issues for years. Since I was in my teens. Nothing debilitating. Just not very happy. Now, I don't feel "as depressed". I just feel tired and frustrated at being tired. I've also had "anger" issues for years now. I'd say since my 20s. But its been really bad since my daughter was born 5 years ago.
I think you all are living in my head! I've dealt with depression for years and years (I highly suspect AF, depression and possibly hypothyroidism goes back almost to childhood, if not that far, for me). I crave carbs (just made GF cupcakes ). I crave chocolate (and finally the last couple weeks feel like I'm taking in enough good stuff that it's not causing cold sores). I have anger issues. I'm tired. And I'm tired of being tired.

So, NAC is supposed to help all of this?
post #287 of 829
Quote:
Originally Posted by MyLittleWonders View Post
I think you all are living in my head! I've dealt with depression for years and years (I highly suspect AF, depression and possibly hypothyroidism goes back almost to childhood, if not that far, for me). I crave carbs (just made GF cupcakes ). I crave chocolate (and finally the last couple weeks feel like I'm taking in enough good stuff that it's not causing cold sores). I have anger issues. I'm tired. And I'm tired of being tired.

So, NAC is supposed to help all of this?
It may. We'll see soon.
post #288 of 829
Thread Starter 
I seem to have clear B5/coA issues. For me, I'm pretty confident that NAC+B5 will make the coA that I'm missing, and that that will solve a bunch of my problems. Combine that with a low protein diet (RDA of protein, not more), and I might have my own custom eating plan. But I haven't tested it out yet. I also have the benefit of *knowing* that genetically, I don't make much BH4 to begin with, so this is a likely explanation.

All that said, yeah, I bet lots of people could easily fall into this trap, and those supps aren't all that crazy. The theory in my head wants to redefine adrenal nutrients as NAC, B5, vit C and biotin. But that might just be because that's what my body seems to need, yk?
post #289 of 829
Quote:
Originally Posted by chlobo View Post
I'm just so amazingly impressed with you ladies. How do you figure this all out and remember it? I can hardly remember my name lately.

You guys are da bomb!
I don't remember it. Something I'm reading triggers something I read, so I go back and look for it...
post #290 of 829
Quote:
Originally Posted by whoMe View Post
I seem to have clear B5/coA issues. For me, I'm pretty confident that NAC+B5 will make the coA that I'm missing, and that that will solve a bunch of my problems. Combine that with a low protein diet (RDA of protein, not more), and I might have my own custom eating plan. But I haven't tested it out yet. I also have the benefit of *knowing* that genetically, I don't make much BH4 to begin with, so this is a likely explanation.

All that said, yeah, I bet lots of people could easily fall into this trap, and those supps aren't all that crazy. The theory in my head wants to redefine adrenal nutrients as NAC, B5, vit C and biotin. But that might just be because that's what my body seems to need, yk?
I hear you on that. I think I'm slowly starting to really narrow-down what we need to be taking (based on "symptoms", dh and I see to be similar in terms of biochemistry). So far, I feel strongly about Vit. C, biotin, magnesium, and will probably add zinc, and depending on your results, NAC and/or B5.
post #291 of 829
Quote:
Originally Posted by Nolansmum View Post
Stress, allergies. Fat and carb utilization.

When I tried to take CLO, or any fish oil I needed a lot of riboflavin to stop from getting cracks in my skin( this was in the summer too.) My body couldn't tolerate that form of fat and it wasn't getting the vitamins from those fats either.

I get snappy after some foods too. It used to happen a lot. Maybe there is something 'pumping' up your nervous system too much?
hey guys,
I just finished listening to a webinar on the Great Plains Laboratories website (it was a live thing tonight that you had to sign up for) and although it was about biomedical treatments for autism, he was talking about a lot of this stuff.

He mentioned that some kids who react badly to the CLO need to take carnitine along with it (500-1,000 mg), something about how the carnitine helps the body to metabolize the fat, get it into the cells. OR he said the reason could be that the individual could be reacting to the flavoring. But if it was because the person could not use or metabolize the oil, the carnitine would help.

You could try carnitine.

He said all this info is on a new website he has just started (this was a physician who works with kids on biomedical treatments for autism) called autismactionplan.org. Haven't checked it out yet, but it sounds like there is a lot of information about this kind of stuff there, protocols for what works for what, etc.
post #292 of 829
Quote:
Originally Posted by MyLittleWonders View Post
Thinking out loud here because my level of knowledge is like Kindergarten level (); if one fits the low GABA/high glutamate description, would supp'ing with GABA help reset that balance? I definitely fit the first two, and the other two come and go. Hmm ...
Quote:
Originally Posted by whoMe View Post
I've heard of mixed results for that... GABA isn't *supposed* to cross the blood brain barrier, so it *shouldn't* help. heartfixer says to avoid glutamate precursors, add Mg and zinc (and a few other things I glossed over)
More from this webinar I just listened to at Great Plains, he was actually talking about anxiety, and that GABA is one supp that might be recommended for it, but he said it works in concert with theanine (an amino acid found in green tea). So when I read your post above, I found this link about theanine:

http://delano.com/Articles/Theanine-Sharpe.html

Theanine resembles glutamate, glutamine, or glutamic acid. Read this link.
post #293 of 829
Thread Starter 
Quote:
Originally Posted by momofmine View Post
More from this webinar I just listened to at Great Plains, he was actually talking about anxiety, and that GABA is one supp that might be recommended for it, but he said it works in concert with theanine (an amino acid found in green tea). So when I read your post above, I found this link about theanine:

http://delano.com/Articles/Theanine-Sharpe.html

Theanine resembles glutamate, glutamine, or glutamic acid. Read this link.
Interesting article, but I'm going to have to wait till morning to actually get anything from it...

Another update over here... Dd's not napping much, and having major ups and downs, pee miss-wise. I credit all the random new food, but I'm not about to take it out. I think she (and I) may be reacting to spinach specifically, though, so I think I'll hold off on that a while. In other TMI news, she's gone from pooping once every 2-4 days, saying 'where are you poo poo?' (I have NO CLUE where that came from ) to random surprise poops 1-3x/day. This is like what she did when she was little, so I think it's a great thing. Oh, and by surprise, I mean surprise to *me* - no misses or anything. And I've noticed a similar improvement in myself : I think the folate gets the most credit for that.
post #294 of 829
Quote:
Originally Posted by whoMe View Post
back to the bacteria... I found an interesting probiotic article:
Oral Administration of Probiotic Escherichia coli after Birth Reduces Frequency of Allergies and Repeated Infections Later in Life (after 10 and 20 Years)

How can I get me some e coli probiotics? I know friendly e coli are common in the gut, but that's not one of the usual lacto/bifido strains, is it?
And you don't get any good ole' E. coli with a C-section.

Progress, ain't it grand.


Pat
post #295 of 829
Quote:
Originally Posted by whoMe View Post

Way too complicated for me tonight. Looks great.

Pat
post #296 of 829
Quote:
Originally Posted by whoMe View Post
Interesting article, but I'm going to have to wait till morning to actually get anything from it...
It was just basically that theanine, an amino acid that is in green tea, resembles glutamate and glutamine. "Once ingested, theanine takes advantage of its resemblance to glutamine to hitch a ride on one of the body’s amino acid transporters, a sodium-dependent system that carries theanine across the intestine 9. A similar transporter ultimately carries theanine across the blood brain barrier as well 10. After getting into the central nervous system, theanine reverts back to its guise as a glutamate mimic and binds to a number of different types of glutamate receptor on nerve cells, albeit with considerably less affinity than glutamate itself 11."

It also says that although glutamte is important for normal brain functioning and long-term memory, too much glutamate can kill nerve cells, which is what happens in some neurological disorders like Alzheimer's. parkinson's, epilepsy.

But, it says, "The good news is that theanine appears capable of blocking cell death caused by kainic acid 13, a neurotoxin known to bind to a particular set of glutamate receptors, as well as by an excess of glutamate itself 14. Furthermore, theanine is effective at protecting nerve cells from injury caused by low levels of oxygen, a condition known as ischemia that is also characterized by excessive glutamate release 15. "

So anyway, I just thought that was interesting, given that this doctor tonight said that theanine and GABA worked in concert with each other, and then this link talked about how theanine resembles glutamate, and in your post you were talking about GABA and glutamate.
post #297 of 829
Thread Starter 
Quote:
Originally Posted by WuWei View Post
And you don't get any good ole' E. coli with a C-section.

Progress, ain't it grand.


Pat
And I was born by C-section. So there ya go.
post #298 of 829
Quote:
Originally Posted by momofmine View Post
It was just basically that theanine, an amino acid that is in green tea, resembles glutamate and glutamine. "Once ingested, theanine takes advantage of its resemblance to glutamine to hitch a ride on one of the body’s amino acid transporters, a sodium-dependent system that carries theanine across the intestine 9. A similar transporter ultimately carries theanine across the blood brain barrier as well 10. After getting into the central nervous system, theanine reverts back to its guise as a glutamate mimic and binds to a number of different types of glutamate receptor on nerve cells, albeit with considerably less affinity than glutamate itself 11."

It also says that although glutamte is important for normal brain functioning and long-term memory, too much glutamate can kill nerve cells, which is what happens in some neurological disorders like Alzheimer's. parkinson's, epilepsy.

But, it says, "The good news is that theanine appears capable of blocking cell death caused by kainic acid 13, a neurotoxin known to bind to a particular set of glutamate receptors, as well as by an excess of glutamate itself 14. Furthermore, theanine is effective at protecting nerve cells from injury caused by low levels of oxygen, a condition known as ischemia that is also characterized by excessive glutamate release 15. "

So anyway, I just thought that was interesting, given that this doctor tonight said that theanine and GABA worked in concert with each other, and then this link talked about how theanine resembles glutamate, and in your post you were talking about GABA and glutamate.
This is fascinating. Thank you for summarizing! I am taking 75 mg of L-theanine via a supplement (in conjunction with a few other things). I wonder, then, if I add GABA to that regimine if I'll have positive results?

I also just realized I'm taking 150 mg of glycine in another supplement (in conjunction with a couple other things). Is there a reason to be concerned about that? (I'm seriously blanking if one of these discussions revolved around too much glycine being bad or was that too much cystine? I need to take written notes while I read here I think.)
post #299 of 829
Quote:
Originally Posted by MyLittleWonders View Post
(I need to take written notes while I read here I think.)


This is a very good idea.
post #300 of 829
Quote:
Originally Posted by whoMe View Post
And I was born by C-section. So there ya go.
Me too.
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