detox pathway guinea pig - Page 3

[WuWei]

Originally Posted by chlobo

Pat,

do you juice the fruit & veggies in the blender or juicer?

I use the juicer. But, you can do soft fruits and baby greens in the blender.

Pat

[WuWei]

Originally Posted by whoMe

Now, for mental sanity (dopamine levels), I need to raise our vit D levels before we can restart the methyl cycle. I might be making my first ever trip to the tanning salon today...

Do you have a link about vit D and dopamine?

Thanks, Pat

[chlobo]

What kind of juicer do you have?

[Theloose]

I'm still looking for a good link and explanation. What I can tell is that VDR (vitamin D receptor) is closely linked, in both schizophrenia (high? dopamine) and Parkinson's disease (low dopamine). Let me know if you find anything!

I got the lead from here

Pertinent to this discussion, Vitamin D stimulate the enzymes that generate dopamine, a good reason to keep your Vitamin D level up, as we need dopamine to defend against microbes and metals, and to keep our mood up.

[WuWei]

Originally Posted by chlobo

What kind of juicer do you have?

Some kind of "Jack LaLane Power Juicer". There are a bunch of them with that name, though, I think.


Pat

[WuWei]

Originally Posted by whoMe

I'm still looking for a good link and explanation. What I can tell is that VDR (vitamin D receptor) is closely linked, in both schizophrenia (high? dopamine) and Parkinson's disease (low dopamine). Let me know if you find anything!

I got the lead from here

Thanks, I'll take a look around. We have all kinds of mental illness in my family. It gets curiouser and curiouser.


Pat

[Astromom]

Originally Posted by WuWei

A splash of ACV or whey or kefir, or even just with water. But, the acid medium/kefir is best, per my understanding.

Perfect, can't wait to try this. Thanks!

Originally Posted by whoMe

So it's all a balance. That's what's making my head : today.

Um, yeah this. I finished reading the liver detox page you linked (that's as far as I've gotten in my sea of open explorer windows referring to all this) and I got to the end and was like "with the kind of balance this all takes, it's a miracle we're even alive!"

[lil_miss_understood]

Originally Posted by whoMe

I'm still looking for a good link and explanation. What I can tell is that VDR (vitamin D receptor) is closely linked, in both schizophrenia (high? dopamine) and Parkinson's disease (low dopamine). Let me know if you find anything!

I got the lead from here

Not certain, but I know they both run in my family... I think it actually has more to do with the adrenal fatigue/underactive thyroid. I read a study which said that even subclinical hypothyroidism can present with delusions and hallucinations and is possibly being mis-diagnosed as mental illnesses including schizophrenia and bipolar disorder- and may even be the cause of the majority of these illnesses.

[Theloose]

So before all this, I was thinking hormonal imbalances were the cause of so many issues. I have no doubt that that's true, and that you can fix a lot by getting the hormones to do what they *should* be doing, whether through nutrition, drugs, hormone replacement, whatever. But there's still the question of why are the hormones messed up to begin with? There's definitely the nutritional factors (iodine and thyroid for example), but the breakdown of those hormones has to be involved as well. And that involves these detox pathways. I'm still trying to understand it, and it's hard to find the right combination of time, energy, motivation and the right level of detailed explanation. And I started all this just a week and a half ago!

Anyways, I wouldn't be at all surprised to find that the root cause is these pathways. Just as one possible route:
Low methylation and/or slow COMT enzyme results in slow breakdown of norepinephrine. Norepinephrine is the neurotransmitter responsible for stimulating the sympathetic (fight or flight) nervous system, and is made by the adrenals. Somehow (not sure of the details) this stimulates the adrenals. When the adrenals are in resistance mode (pre-fatigue, all output is high) the thyroid can downregulate itself (fuzzy on details again) and you end up hypothyroid keep it up, and the adrenals fatigue. All because you weren't methylating right.

And if your dopamine levels don't match your methyl/COMT levels, you get mental symptoms. That part is pretty well established.

[lil_miss_understood]

That's actually kind of my point. I'm not expressing myself well lately- I'm blaming partly placenta brain and partly just sheer exhaustion still (all I've been wanting to do now that I'm able to eat regularly is eat and sleep).

[gilamama]

i wish i understood what you guys were talking about. really really...

[chlobo]

Tell me about it.

It all sounds important but I don't understand any of it.

[farmerjess]

ok, i remember you saying that everyone had to figure this out for themselves...How do you go about figuring out which of your detox pathways are blocked? Do I just try working on them one at a time? I need to know what to do..... Because you don't have enough to do could you make some sort of "if you feel this, try this?"

I think I have some adrenal fatigue, how to heal that? THank you for all of this, your knowledge is invaluable.

[lil_miss_understood]

Jess,
I think the problem is that there really hasn't been a whole lot of research into unblocking detox pathways. If there had been, there would be a passel of doctors specializing in it, I'm sure. whoMe is in groundbreaking territory (although there are some trailblazers ahead of her, such as Panserbjorne). There just isn't enough information, I don't think, to be able to say "If you're tired and your right leg hurts, your glucoridination (sp?) cycle is blocked." or "If you get hives on your hiney after eating pineapple, you need more b6."
whoMe is doing a *lot* of mind-bending research, then trying to break it down so that anyone can understand it, as well as using herself and her dd as "guinea pigs" to test the information she's reading- "If I do this, to try to unblock this pathway, what happens? How do I feel? Is it affecting anything else?" (I think she needs a home lab. )

[Annikate]

I have been lurking along a little and there are doctors who know about this and specialize in it and they are called DAN doctors. It's not really groundbreaking territory, it falls under the category of immune response. I have learned a lot about all of this from my dd's DAN who is an expert in *all* of this. I wish I could tap into his brain and then regurgitate all that he knows and has told me over the years.

I know that my dd is not a good methylator - I bet I'm not either - and will soon find out. Glutathione seems to work wonders for my dd1, while other things sort of 'jump started' my dd2's immune system and she is now a good detoxifier and is doing it on her own.

I'm interested in all of this, I just wish I had the time to jump in more.

I'm dealing w/adrenal fatigue at the moment but perhaps when I'm over that I'll have more time and brain power.

[lil_miss_understood]

Thank you, Annikate! I had no idea that's what a DAN doctor did.
I know all about dealing with adrenal fatigue (let me rephrase- I know all about *having* adrenal fatigue )... I'm sure a lot of the other moms here do too.

[changingseasons]

Dr. Kenneth Bock talks about methylation a LOT in Healing the New Childhood Epidemics. I just finished reading it, which is good, because otherwise I would have been REALLY lost when whome started posting about it. I really need to go buy that book. (I keep having to return it to the library just when I'm really deep into it.)

[farmerjess]

thanks cs, i will get that book. the (extreme, longterm) ED just doesn't feel right to me, but that seems like where we're headed and i don't know what else to do. i don't mean to pressure you whome

-jessi(extremely overwhelmed new mamaof a 4 month old)

[Theloose]

Yeah, this stuff is pretty well researched and even understood. Doctors are using it and it seems to work. The biggest roadblock that I see is how it's so complicated that only a few really understand and know what's going on. And those few are a limited resource that get rationed for those with the biggest issues (autism). Cause you know, we're 'just' dealing with a few food intolerances, and the severity is all in our heads...

And what's funny/ironic? I think I have a pretty severe case of ADD right now, meaning I can't focus/think about anything else. Nothing. And without that obsession, I wouldn't have been able to put it together. The ironic part? My first step to healing is to improve vitamin D status, which should raise dopamine, which should get rid of the ADD. Hopefully I'll have gotten you all up to speed by then!

[lil_miss_understood]

Originally Posted by whoMe

Yeah, this stuff is pretty well researched and even understood. Doctors are using it and it seems to work. The biggest roadblock that I see is how it's so complicated that only a few really understand and know what's going on. And those few are a limited resource that get rationed for those with the biggest issues (autism). Cause you know, we're 'just' dealing with a few food intolerances, and the severity is all in our heads...

And what's funny/ironic? I think I have a pretty severe case of ADD right now, meaning I can't focus/think about anything else. Nothing. And without that obsession, I wouldn't have been able to put it together. The ironic part? My first step to healing is to improve vitamin D status, which should raise dopamine, which should get rid of the ADD. Hopefully I'll have gotten you all up to speed by then!

Almost makes me wish I hadn't made the changes in ds1's diet way back when that prevented him from being dx'd with autism- "just" ADHD, and now ADD.
Almost.