Originally Posted by KatWrangler
Finally reading this thread.
I was told my daughters defect was not the result of lack of Folic Acid. This is by our original Pediatric Neurosurgeon. That it was a fluke that happens at 6-8 weeks gestation. Another words they don't know.
I did take prescription strength folic acid with DD2. She was born with a hemangioma but the MRI turned out that she is fine.
Have you guys looked at what Duke is doing?http://www.chg.duke.edu/diseases/ntd.html
Not sure if there is any info here or not.http://www.spinabifidamoms.com/english/index.html
In all the stuff I'm looking up, they're surprised to find inconsistent results, and half the studies say there's no correlation with MTHFR genotype and/or folate status and
But I don't think I've found one yet that takes into account the difference between food folate and folic acid. Some of them talk about supplements vs food, but they include fortified grains as food sources, best I can tell
Did you look into 5-MTHF (i.e. folapro) instead of folic acid? If you have an MTHFR enzyme with 'reduced activity' then as you supplement lots of folic acid, you raise both your active folate levels *and* your useless folic acid levels. Then the two compete in your body, effectively lowering your folate levels again.
I'm trying to pick out what's an effect of folate vs homocysteine. (I have reduced MTHFR function but normal homocysteine) The one study in my last post says homocysteine is a major variable for NTD's, but I haven't found a similar study for clefts yet. My current mid-research feeling is that it looks like it's more of a general folate thing.