Another Hib qu - how likely to get it within the week after shot?

[calendula]

I've been reading on these forums that a week after getting Hib a child would be more susceptible to actually getting the disease. How likely is this? Are there any stats?
Basically should I bring my child straight home after getting shots or is it really not that big a deal?!

Thanks.

[Th1Th2]

Originally Posted by calendula

I've been reading on these forums that a week after getting Hib a child would be more susceptible to actually getting the disease. How likely is this? Are there any stats?
Basically should I bring my child straight home after getting shots or is it really not that big a deal?!

Thanks.

The vaccine package insert says it all:

PedvaxHIB* [Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate)] is a highly purified capsular polysaccharide (polyribosylribitol phosphate or PRP) of Haemophilus influenzae type b (Haemophilus b, Ross strain) that is covalently bound to an outer membrane protein complex (OMPC) of the B11 strain of Neisseria meningitidis serogroup B.

Haemophilus influenzae type b (Hib) was the most frequent cause of bacterial meningitis and a leading cause of serious,systemic bacterial disease in young children worldwide.1,2,3,4

Why give something that's causing the disease?

[calendula]

oh, so they are more susceptible from the vax itself. I had been thinking they were more susceptible to developing it, however it normally develops.

is this correct?

[Th1Th2]

Normal, healthy and NON-DISEASED persons are mistakenly and intentionally termed as SUSCEPTIBLE by the medical community in order for them to get vaccinated, that is, to make them DISEASED. Why vaccinate when you can remain non-diseased?

[calendula]

I wasn't looking for debate just an answer to the original question. Thanks anyway.

[Th1Th2]

First off I am not debating.
I am just pointing out that Hib vaccines will obviously cause Hib disease because it contains the Hib bacteria. Thus, persons who had received the Hib vaccine are no longer susceptible because they already have the evidence of the disease.

[Marnica]

Originally Posted by calendula

I've been reading on these forums that a week after getting Hib a child would be more susceptible to actually getting the disease. How likely is this? Are there any stats?
Basically should I bring my child straight home after getting shots or is it really not that big a deal?!

Thanks.

I may be wrong on this but I believe that the concern about susceptibility for 7-14 days after vaccination for Hib was about the old polysacchride vaccine and not the newer conjugated one, but Im not 100% sure on that. Hopefully somebody else can chime in.

[mamakay]

Originally Posted by Marnica

I may be wrong on this but I believe that the concern about susceptibility for 7-14 days after vaccination for Hib was about the old polysacchride vaccine and not the newer conjugated one, but Im not 100% sure on that. Hopefully somebody else can chime in.

Yep. It was the old vax that did that.
No similar worries with the new one.

[mamakay]

Originally Posted by Th1Th2

First off I am not debating.
I am just pointing out that Hib vaccines will obviously cause Hib disease because it contains the Hib bacteria. Thus, persons who had received the Hib vaccine are no longer susceptible because they already have the evidence of the disease.

The hib vax is not live and can not cause hib disease. It doesn't even contain a whole piece of the bacteria.

[girlsmamma2]

really? So there is a new one that doesn't have that concern? That is a scary disease to me but it's also scary to be so susceptible to it after getting vaxed. The Dr. Sears book states that you are more at risk of developing a severe, not even just HIB, but he states severe HIB infection up to 5 days after the shot. But since HIB is so rare he says because of the vaccine, being exposed is very risky.

So is this info outdated then and how can I find a link for info on it? From what you said, the newer vaxes don't have this risk anymore?

[girlsmamma2]

oops, I meant being exposed is rare.....sorry

[mamakay]

Yeah, his info is outdated.
I'm really not quite sure how to prove that the new one doesn't do that, though.

Let me see what I can find...

[Th1Th2]

Originally Posted by mamakay

The hib vax is not live and can not cause hib disease. It doesn't even contain a whole piece of the bacteria.

If the Hib vaccine DOESN'T cause Hib disease then where do you get the immunity from in the ABSENCE of the disease?

[anewmama]

I hope not. My daughter is now sleeping off the dose she got today. Luckily, due to her age, this is the only one she will be getting.

Mamakay, why only 1 for her age (22.5 months).... is it that they can mount a better immune response when they are older? Is that the primary reason the doses for vaccines on the delayed schedule are often less in number than if they are started when they are younger?

[Th1Th2]

The vaccine package insert states:

As reported with Haemophilus b polysaccharide vaccines,24 cases of H influenzae type b disease may occur subsequent to vaccination and prior to the onset of protective effects of the vaccine.

http://www.vaccineshoppe.com/US_PDF/...5122_10.06.pdf

The equation will never lie, Hib vaccine = Hib disease.

[mamakay]

Originally Posted by Th1Th2

If the Hib vaccine DOESN'T cause Hib disease then where do you get the immunity from in the ABSENCE of the disease?

The polysaccharide antigen.

[mamakay]

Originally Posted by Th1Th2

The vaccine package insert states:



The equation will never lie, Hib vaccine = Hib disease.

Yes, it takes a week for immunity to fully develop. That does not say that the Hib vaccine causes Hib disease.

[mamakay]

Originally Posted by anewmama

I hope not. My daughter is now sleeping off the dose she got today. Luckily, due to her age, this is the only one she will be getting.

Mamakay, why only 1 for her age (22.5 months).... is it that they can mount a better immune response when they are older? Is that the primary reason the doses for vaccines on the delayed schedule are often less in number than if they are started when they are younger?

Well, those immunogenicity studies were done pre and mid vaccine, when most kids had already been exposed to the real deal several times. So...maybe eventually they'll decide that older kids do need more doses in the absense of circulation.

[Th1Th2]

Originally Posted by mamakay

The polysaccharide antigen.

You mean the polysaccharide antigen of Hib bacteria in the vaccine that is causing the disease?

An important virulence factor of the Hib bacterium is its polysaccharide capsule (PRP).

PedvaxHIB* [Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate)] is a highly purified capsular polysaccharide (polyribosylribitol phosphate or PRP) of Haemophilus influenzae type b (Haemophilus b, Ross strain) that is covalently bound to an outer membrane protein complex (OMPC) of the B11 strain of Neisseria meningitidis serogroup B.

http://www.merck.com/product/usa/pi_.../pedvax_pi.pdf

[Th1Th2]

Originally Posted by mamakay

Yes, it takes a week for immunity to fully develop. That does not say that the Hib vaccine causes Hib disease.

Again, are you saying that the polysaccharide capsule of Hib bacteria found in Hib vaccines will NOT cause Hib disease?

An important virulence factor of the Hib bacterium is its polysaccharide capsule (PRP).

http://www.merck.com/product/usa/pi_.../pedvax_pi.pdf

Hib disease, also known as Haemophilus influenzae type b, is caused by small bacteria that can develop into serious, often life-threatening illnesses, with a number of complications. http://www.hibdisease.com/parents_faq.html