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sulfur sensitivity

post #1 of 179
Thread Starter 
A bunch of people seem to be identifying this as an issue, lately, so it gets its own thread

My understanding is that sulfur sensitivity happens when the SUOX (sulfoxidation?) enzyme gets overloaded. SUOX converts sulfite into sulfate. Sulfate is one of the detox pathways.

SUOX requires B6 and molybdenum. Too MUCH B6 and/or molybdenum can also create an issue.

Sulfite comes from foods and additives, other forms of sulfur come from foods, and sulfite is also an end product of the transsulfuration sequence. Transsulfuration needs magnesium and B6 (chocolate cravings can mean your body wants to push more down this pathway). It can be REALLY active in some people. To limit it (so as to not produce so much sulfite), you can push the methyl cycle (folate/B12) and limit methionine (a protein, but don't eliminate it completely!)

This isn't our issue, but I'm curious anyway. I'm not an expert yet!
post #2 of 179
This is interesting....I have severe reactions to Sulfa based drugs, and i have been noticing lately reactions to foods high in sulfates.

I get really irritated, and itchy, and my ADHD goes insane.

DD was prescribed antibiotics and she reacted really bad to them. She was running around like a crazy lunatic and wouldn't sleep and biting things.....i wounder if its the same thing.

Looking forward to more info.
post #3 of 179
subbing.... be back tomorrow to read further.
post #4 of 179
Wait- sulfa drugs aren't the same issue, are they?
post #5 of 179
Thread Starter 
Quote:
Originally Posted by tinyblackdot View Post
This is interesting....I have severe reactions to Sulfa based drugs, and i have been noticing lately reactions to foods high in sulfates.

I get really irritated, and itchy, and my ADHD goes insane.

DD was prescribed antibiotics and she reacted really bad to them. She was running around like a crazy lunatic and wouldn't sleep and biting things.....i wounder if its the same thing.

Looking forward to more info.
Sulfa drugs and most antibiotics are detoxed via acetylation (coenzyme A, requires B5, cysteine, magnesium, biotin, thiamine). Confusing, isn't it?

And just so we're all on the same page, you're probably reacting to sulfITEs in foods, not sulfATEs.

Epsom salt baths (magnesium sulfate) might actually be helpful as a way to bypass the SUOX enzyme.
post #6 of 179
Quote:
Originally Posted by whoMe View Post
Sulfa drugs and most antibiotics are detoxed via acetylation (coenzyme A, requires B5, cysteine, magnesium, biotin, thiamine). Confusing, isn't it?

And just so we're all on the same page, you're probably reacting to sulfITEs in foods, not sulfATEs.

Epsom salt baths (magnesium sulfate) might actually be helpful as a way to bypass the SUOX enzyme.
Wait wait wait.....im confused.
post #7 of 179
Thread Starter 
Quote:
Originally Posted by tinyblackdot View Post
Wait wait wait.....im confused.
That's cause this is quite possibly the most confusing topic on earth :

Intro to detox video


Sulfite and sulfate are two different forms of sulfur. Sulfite is bad and needs to be eliminated. Sulfate is good and can be used to clear out other toxins. Sulfites are a common additive to certain foods.

A little better?
post #8 of 179
Quote:
Originally Posted by whoMe View Post
That's cause this is quite possibly the most confusing topic on earth

Intro to detox video


Sulfite and sulfate are two different forms of sulfur. Sulfite is bad and needs to be eliminated. Sulfate is good and can be used to clear out other toxins. Sulfites are a common additive to certain foods.

A little better?
Yes!

Hm.....this is really interesting! My dd has had digestive issues since birth really (she had antibiotics in utero and in the NICU) and we cannot pin point the problem! But maybe this is the issue....or maybe its all linked to gether somehow at least. So epsom salt bathes eh?
post #9 of 179
I don't know if this is relevant - but it says liver detoxification phase I & II and sulfation (and it's from the blog of the new HCP I found - exciting!): http://cemmed.wordpress.com/
post #10 of 179
Interesting topic. Another sub-segment, that I think the kids and I are in, do better on a high-sulfur diet. We haven't actually tested it, we made some guesses early on (it's common in the mercury world to need either a high-sulfur or a low-sulfur diet, separate from the GFCF issue) and given how I've improved (and our massive egg consumption) I think we guessed right. Some folks do great with supplemental MSM, and some feel horrible (and presumably some people don't have a big response one way or the other).

So this would imply that sulfate (like in epsom salts) are our limiting factor in the sulfation process?
post #11 of 179
It's been a long time since I really researched all this so I could be wrong, but my understanding is that sulfur in foods is converted into sulfates in the body. So epsom salt baths are often recommended to provide a readily usable source of sulfates. Sulfates can help detox phenols.

I know of one person who figured out her DS' sensitivity to sulfur-containing foods after a reaction to sulfa drugs, so IMO a reaction to sulfa drugs could indicate a problem with sulfur-containing foods or sulfates.

And my DS reactions to sulfur-containing foods AND epsom salts (when I take them), so just because sulfates are useful doesn't mean people don't react to them.

Sulfur sensitivity can be an indicator of problems with oxalates, yet another food chemical.
post #12 of 179

Sulfation issues

I am new to this group. But I really find the discussion to be very informative. It seems like you guys know a lot about detox pathways. I am working on the same issue. Currently working on my sulfation pathway; therefore, in this regards do you recommend any supplements? Currently I take Mo but it decreases Cu so not sure if I should continue it in the long run?

Thanks in advance!!!
Cool girl
post #13 of 179
Wait, wait, wait. People keep mentioning sulfa drugs, but I was under the impression that they really had nothing to do with sulfur or sulfite sensitivities.

Quote:
Originally Posted by kortner View Post
I don't know if this is relevant - but it says liver detoxification phase I & II and sulfation (and it's from the blog of the new HCP I found - exciting!): http://cemmed.wordpress.com/
I found this part interesting:
Quote:
Sulfate is essential in forming the mucin proteins which line the gut walls. These have two main functions–they stop the gut contents from sticking and they block transport of toxins from the gut to the bloodstream. Low plasma sulfate is found in patients with irritable bowel syndrome. Irritable bowel syndrome is identified with symptoms that may include constipation, diarrhea, alternating bowel habit, abdominal bloating and pain, and flatulence.
post #14 of 179
Quote:
Originally Posted by changingseasons View Post



I found this part interesting:
Ok so is that part saying that people with IBS need more sulfates or none?

Im completely lost here, this is my first intro to detox pathways so bear with me.

Where can i find a good book on all of this detox stuff?

I am reading the Yeast hanbook right now, and i think its interesting that the first video mentioned that if you have too much bad bacteria they will steal your flags and keep the toxins in your body.....
post #15 of 179
Quote:
Originally Posted by tinyblackdot View Post
Ok so is that part saying that people with IBS need more sulfates or none?
I think it means you need MORE sulfates.

So either you need to do epsom salt baths, or get your body to properly convert sulfites and eat more of them. And how do you do that again?
post #16 of 179
Quote:
Originally Posted by whoMe View Post

Sulfite comes from foods and additives, other forms of sulfur come from foods, and sulfite is also an end product of the transsulfuration sequence.
Not to confuse things, but I thought sulFIDE was the end product of the transulfuration sequence??


But, per my googling, I get confused with all of the sulf...s.

Check out this book "Neurotube Defects" about the transulfuration process. http://books.google.com/books?id=lkh...sult#PPA177,M1

Pat
post #17 of 179
Quote:
Originally Posted by changingseasons View Post
I think it means you need MORE sulfates.

So either you need to do epsom salt baths, or get your body to properly convert sulfites and eat more of them. And how do you do that again?
hm....by having the correct bacteria in your gut?

Am i close?
post #18 of 179
I have no idea... I was kind of hoping someone else would know that answer to that question.
post #19 of 179
Thread Starter 
I need to go back and read the links, but here's my understanding:

SUOX is an enzyme that converts toxic sulfur forms into helpful sulfur forms. Sulfate is the end product, and it makes up the sulfation detox pathway.

If you're sulfur sensitive, then the SUOX enzyme gets overloaded. Then you have two issues:
-first, too many toxic sulfur compounds floating around
-second, not enough sulfate for detoxing.

The first would show up as a sensitivity to dietary sulfur (eggs, brassicas, wine/sulfites, etc, maybe sulfa drugs?)

The second would show up as difficulty in detoxing adrenal hormones, thyroid hormones, salicylates, food additives, environmental toxins...

If you have the second, but not the first, then sulfur foods will probably be your friends. (I think this is me, BTW)

To address the first, you figure out why your SUOX can't keep up. Reasons that I know of include:
-too much or too little B6
-too much or too little molybdenum
-fast transsulfuration (sulfite or hydrogen sulfide are end products)
-genetic tendency (so nutrients are extra important)

To address the second, epsom salts are helpful because they're preformed sulfate that can be used for detox directly.

Now are we on the same page?
post #20 of 179
Quote:
Originally Posted by whoMe View Post
I need to go back and read the links, but here's my understanding:

SUOX is an enzyme that converts toxic sulfur forms into helpful sulfur forms. Sulfate is the end product, and it makes up the sulfation detox pathway.

If you're sulfur sensitive, then the SUOX enzyme gets overloaded. Then you have two issues:
-first, too many toxic sulfur compounds floating around
-second, not enough sulfate for detoxing.

The first would show up as a sensitivity to dietary sulfur (eggs, brassicas, wine/sulfites, etc, maybe sulfa drugs?)

The second would show up as difficulty in detoxing adrenal hormones, thyroid hormones, salicylates, food additives, environmental toxins...

If you have the second, but not the first, then sulfur foods will probably be your friends. (I think this is me, BTW)

To address the first, you figure out why your SUOX can't keep up. Reasons that I know of include:
-too much or too little B6
-too much or too little molybdenum
-fast transsulfuration (sulfite or hydrogen sulfide are end products)
-genetic tendency (so nutrients are extra important)

To address the second, epsom salts are helpful because they're preformed sulfate that can be used for detox directly.

Now are we on the same page?
ok ok....now where are sulfites and sulfates found?
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