CDC Pink Book -
Menactra (MCV) and Meningococcal Polysaccharide Vaccine (MPSV) are the vaccines licensed for use in the US. Are these the same vaccines for there? Which serogroups are covered if there is a different one? MCV (recommended more, supposed better efficacy and longer duration of protection) contains serogroups A, C, Y and W-135.
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| Infants younger than 12 months of age have the highest rates of disease. |
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| In 2001, 65% of cases among infants aged less than 1 year were caused by serogroup B, for which no vaccine is available in the United States. |
About MPSV-
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| The vaccine is generally not effective in children younger than 18 months of age. The response to the vaccine is typical of a T-cell independent antigen, with an age-dependent response, and poor immunogenicity in children younger than 2 years of age. |
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In one study,
efficacy declined from more than 90% to less than 10% 3 years
after vaccination among children who were younger than
4 years of age when vaccinated. |
Quote:
| Routine vaccination of civilians with MPSV is not recommended because of its relative ineffectiveness in children younger than 2 years of age (the age group with the highest risk for sporadic disease) and because of its relatively short duration of protection. |
It doesn't give much info on MCV but it isn't for the before age two group.
