"It has been known for almost 15 years that deregulated expression of the EGF receptor and ErbB2 contribute to the development and malignancy of breast cancer."http://breast-cancer-research.com/content/2/3/154Overview of tyrosine kinase inhibitors in clinical breast cancer
Goal: tyrosine kinase inhibition.
***Comprehensive Natural Cancer treatments/herbs: http://www.cancercliniconline.com/SI...ANCERHERBS.htmThymoquinone inhibited cell proliferation and suppressed the activation of AKT and extracellular signal-regulated kinase. http://mct.aacrjournals.org/cgi/cont...tract/7/7/1789
Nigella sativa (lay overview)http://en.wikipedia.org/wiki/Gossypium_hirsutum
Glycine max "acting as a tyrosine kinase inhibitor "
Isoflavones (such as genistein & daidzein) and saponins isolated from Glycine max inhibit growth & spread of various cancers such as cancers of the breast, uterus, cervix, ovary, lung, stomach, colon, pancreas, liver, kidney, urinary bladder, prostate, testis, oral cavity, larynx, and thyroid. Glycine max
(seeds) is also effective in nasopharyngeal carcinoma, skin cancer, malignant lymphoma, rhabdomyosarcoma, neuroblastoma, malignant brain tumours and leukaemia. Isoflavones & saponins isolated from Glycine max possess wide ranging anticancer properties such as inhibition of cancer cell proliferation, promotion of cell differentiation and induction of apoptosis.
Genistein works by blocking angiogenesis (formation of new blood vessel), acting as a tyrosine kinase inhibitor
(the mechanism of action of many new cancer drugs) and inducing apoptosis. http://en.wikipedia.org/wiki/Genistein
Insulin stimulates the tyrosine kinase activity of its receptor resulting in the tyrosine phosphorylation of pp185, http://www.mombu.com/medicine/diet-a...s-1477632.htmlhttp://www.ncbi.nlm.nih.gov/pubmed/12947321http://www.journals.elsevierhealth.c...00045/abstractNigella sativa (black seed oil)
Thymoquinone inhibited vascular endothelial growth factor–induced
extracellular signal-regulated kinase activation but showed no
inhibitory effects on vascular endothelial growth factor receptor 2
activation. Overall, our results indicate that thymoquinone inhibits
tumor angiogenesis and tumor growth and could be used as a potential
drug candidate for cancer therapy.
[Mol Cancer Ther 2008;7(7):1789–96]http://mct.aacrjournals.org/content/7/7/1789.abstract
The pharmacological investigations of the seed extracts reveal a broad spectrum of activities including immunopotentiation (5) and antihistaminic (6), antidiabetic (7), anti-hypertensive (8), anti-inflammatory (9), and antimicrobial activities (10). Many of these activities have been attributed to the quinone constituents of the seed (11,12).
Furthermore, blackseed preparations may have a cancer chemopreventive potential and may reduce the toxicity of standard antineoplastic drugs (13)
These results demonstrate either that the essential oil has an anti-metastatic activity in mice or that it inhibits or delays metastasis by rapid reduction of primary tumor volume at the site of induction.
On the other hand, to evaluate the side effects of these extracts, we tested their cytotoxicity toward normal human peripheral blood mononuclear cells. Interestingly, only minimal cytotoxicity was observed for all extracts.http://www.sciencedirect.com/science...edd8a9dfeb4570http://www.kitchendoctor.com/articles/blackcumin.htmlhttp://www.globinmed.com/IMRContent/...px?id=SAF00025http://www.scielo.br/scielo.php?scri...lng=en&nrm=isohttp://www.mskcc.org/mskcc/html/69141.cfmhttp://www.feelgoodfood.com/feel-goo...gella-seed.phphttp://www.ayubmed.edu.pk/JAMC/PAST/20-2/Randhawa.pdf
Nigella is considered a BRM because studies show extracts from the seeds are toxic to cancer cells and, in mice, prevent blood cell toxicity caused by the anti-cancer drug cisplatin.1 The active components of nigella seeds are the volatile oils thymoquinoline and dithymoquinone, both of which inhibit tumor cells in laboratory experiments—even tumor cells resistant to anti-cancer drugs
N. sativa was tested in volunteers with a low helper T-cell to suppressor T-cell ratio. The results indicated an increase in the helper T-cell population in the experimental group. Further, the helper T-cell to suppressor T-cell ratio increased while the ratio within the control groups remain the same.
Nair et al. (1991) investigated the effects of N. sativa as potential protective agents against cisplatin-induced toxicity in mice. Some protective effects were shown by the use of N. sativa extracts.http://www.patentstorm.us/patents/5653981/fulltext.html
N. sativa has been found to be most effective when administered at a dosage of 30 g per day, with an effective range of 20-40 g per day.
Nigella also stimulates the immune system, as shown in an experiment conducted with human lymphocytic white blood cells. Cells treated with nigella-seed proteins produced greater amounts of cytokines, specifically interleukin-1-beta and tumor necrosis factor alpha.4 How and if this is important to treating cancer is not yet established. http://www.newhope.com/nutritionscie..._00/cancer.cfmhttp://www.angelfire.com/ns2/nigella-sativa/http://www.informaworld.com/smpp/content~content=a790249221~db=allhttp://www.sciencedirect.com/science...5820f5d169e749http://cat.inist.fr/?aModele=afficheN&cpsidt=17836870http://www.medindia.net/news/Traditi...er-36922-1.htm
glutathionehttp://www.patentstorm.us/patents/5653981/claims.htmlglutathione is increased with black seed, inhibits tumors basically
The anti-oxidant glutathione is composed of the amino acids glycine, glutamic acid, and cysteine. Foods that increase glutathione levels in the body include cruciferous vegetables (Brussels sprouts, cauliflower, broccoli, cabbage, kale, bok choy, cress, mustard, horseradish, turnips, rutabagas, kohlrabi), avocados, ripe seeds of green beans, red beets, the herb rosemary, grape seed extract, bilberry extract, curcumin found in turmeric, whey protein powder, and Pycnogenol from pine bark. A food that is particularly high in glutathione precursers is whey made from milk.http://www.alkalizeforhealth.net/longevity.htmVitamin C elevates red blood cell glutathione in healthy adults. Fresh fruits and vegetables provide excellent levels of glutathione. Per serving, asparagus, avocadoes, asparagus, squash, okra, cauliflower, broccoli, potatoes, spinach, walnuts, garlic, and raw tomatoes have the highest glutathione content compared to other vegetables and are particularly rich dietary sources of glutathione.
The authors of this study concluded "it is not feasible to increase circulating glutathione to a clinically beneficial extent by the oral administrating of a single dose of 3 g of glutathione [supplement]."http://www.selfgrowth.com/articles/D...utathione.htmlNatural Foods That Boost Glutathione Levels:
Asparagus is a leading source of glutathione. Foods like broccoli, avocado and spinach are also known to boost glutathione levels. Raw eggs, garlic and fresh unprocessed meats contain high levels of sulphur-containing amino acids and help to maintain optimal glutathione levels.
Undenatured Whey Protein has been shown in numerous scientific studies and clinical trials to optimize glutathione levels.
Curcumin (Turmeric) has been found to increase expression of the glutathione S-transferase and protect neurons exposed to oxidant stress.
Balloon Flower Root Changkil saponins (CKS) isolated from the roots of the Chinese herbal medicine, Platycodon grandiflorum. Balloon Flower Root or Jie Geng, have been found to increase intracellular glutathione (GSH) content and significantly reduce oxidative injury to liver cells, minimize cell death and lipid peroxidation.
Selenium is a co-factor for the enzyme glutathione peroxidase. (brazil nuts)http://www.naturalhealthweb.com/articles/shah5.htmlMilk Thistle is a Food Sources That Boost Glutathione Naturally!
glutathione levels cannot be increased to a clinically beneficial extent by orally ingesting a single dose of (supplemental) glutathione. (1) This is because glutathione is manufactured inside the cell, from its precursor amino acids, glycine, glutamate and cystine.
Hence food sources or supplements that increase glutathione must either provide the precursors of glutathione, or enhance its production by some other means.
The manufacture of glutathione in cells is limited by the levels of its sulphur-containing precursor amino acid, cysteine. Food sources for cysteine include poultry, yogurt, oats, wheat germ, egg yolks, red peppers, garlic, onions, broccoli, and Brussels sprouts.http://ezinearticles.com/?Food-Sourc...urally&id=1177
Foods to help Phase 1 Detox:
Melons and peppers
Tomatillos, papaya, plantains, carambola and guava
Foods to Help Phase Two Detoxification
Papaya and Avocado
Foods for the General Health of the Liver
Soy Beans contain lecithin which helps the liver break down fats and helps reduce high cholesterol levels; lecithin also helps maintain healthy membranes around liver cells.
long list of nigella sativa researchhttp://www.bio-asli.com/nil/e_nil/e_rujhs.asp
Nutritional value, functional properties and nutraceutical applications of black cumin (nigella sativa) (need full text) http://www3.interscience.wiley.com/j...89030/abstractThymoquinone, a component derived from the medial plant Nigella sativa, has been used for medical purposes for more than 2,000 years. Recent studies reported that thymoquinone exhibited inhibitory effects on cell proliferation of many cancer cell lines. http://mct.aacrjournals.org/cgi/cont...tract/7/7/1789http://www.biomedexperts.com/Abstrac...-regulated_kin
low toxicity: http://www.highbeam.com/doc/1G1-93210558.html
The pharmacological actions of the crude extracts of the seeds (and some of its active constituents, e.g. volatile oil and thymoquinone) that have been reported include protection against nephrotoxicity and hepatotoxicity induced by either disease or chemicals. The seeds/oil have antiinflammatory, analgesic, antipyretic, antimicrobial and antineoplastic activity. The oil decreases blood pressure and increases respiration. Treatment of rats with the seed extract for up to 12 weeks has been reported to induce changes in the haemogram that include an increase in both the packed cell volume (PCV) and haemoglobin (Hb), and a decrease in plasma concentrations of cholesterol, triglycerides and glucose.
The seeds are characterized by a very low degree of toxicity.http://www3.interscience.wiley.com/j...25344/abstracthttp://www.naturelegacy.com/black_se...tent&Itemid=21Restriction of tyrosine (Tyr) and phenylalanine (Phe) inhibited growth and metastasis of B16BL6 murine melanoma and arrested these cells in the G0-G1 phase of the cell cycle. http://cancerres.aacrjournals.org/cg...tract/59/3/758
The natural tyrosine kinase inhibitor Genistein
produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. http://www.scientistlive.com/Europea..._killer/20411/http://www.naturalpath.com/middle-ea...creatic-cancerhttp://www.jeffersonhospital.org/new...icle16250.htmlhttp://www.thaindian.com/newsportal/..._10050578.htmlhttp://www.turntoislam.com/forum/showthread.php?t=28827http://www.ecrater.com/product.php?pid=234935http://www.nzhealth.net.nz/herbs/kalongi.shtmlhttp://dailystrength.org/c/Morgellon...iva-good-fighthttp://www.scialert.net/qredirect.ph...451&linkid=pdf
I researched anti-oxidants and chemotherapy at the hospital library. I found a bunch of research which *supports* the use of anti-oxidants alongside chemotherapy. Including the admonition to *include* anti-oxidants.Genistein, a natural isoflavonoid phytoestrogen, is a strong inhibitor of protein tyrosine kinases.
"Our results indicate that the natural isoflavone genistein antagonizes tumor cell growth through both cell-cycle arrest and induction of apoptosis and suggest that it could be a promising new agent in cancer therapy. "http://www.ncbi.nlm.nih.gov/pubmed/8207961"Dietary means were employed to reduce the intake of phenylalanine and tyrosine in patients with advanced malignant melanoma. The limitation of substrate, i.e., tyrosine, might, therefore, result in selective energy deprivation with consequent inhibition of tumor growth. In 3 of the 5 patients studied there was a clear relationship between the institution of the dietary regimen and the onset of regressive changes in the metastatic disease. There was a further direct correlation between the serum phenylalanine and tyrosine levels and the progression of the disease. This regimen, although beneficial with respect to some of the metastases and probably nutritionally sound, is cumbersome, complex and unpalatable, making its application difficult."http://www3.interscience.wiley.com/j...62467/abstracthttp://books.google.com/books?id=NEf...um=6&ct=result
See top of "page 7": http://jem.rupress.org/cgi/reprint/137/1/1.pdf
Current medical research is focused on finding a patentable way to harness the benefits of Thymoquinone separate from the nigella sativa seeds. It is cheap to purchase Black seeds (nigella sativa) any middle eastern or Indian store.
(maybe call first). It will be called either black seed or habbat-ul-baraka or kalonji (indian stores)
. They look similar to sesame seeds but black and they taste cumin(ish), or you could see if they have the oil. NOT black sesame seeds though. Must be nigella sativa (latin name).
I found them locally, easily. About $5 for a month supply. You could order from www.sweetsunnah.com
so if you can wait it's better to do that. They're stuff is cold pressed, pure and you can get caps as well if you don't want to do oil/seeds.
Additionally, there is a lot of new information about the role of the MTHFR genetic alteration and folic acid supplemented associated cancers. The supplemented folic acid "fills up" the folate receptor sites so that folate can not be utilized by the body properly.
While googling everything cancer@ every medical research study on the net for my mom's pancreatic cancer, I found this research dated June 2007:
The researchers also say that they uncovered another interesting trend that some people who received these nutrients from multivitamin pills had an increased risk of developing the disease. According to the researchers, individuals who said they used multivitamins, and whose blood showed traces of these nutrients, had a 139 percent increased relative risk of developing pancreatic cancer.
Another separate study of 81,922 women and men, specific to folate from food sources. CONCLUSION: Our results suggest that increased intake of folate from food sources, but not from supplements, may be associated with a reduced risk of pancreatic cancer.
It appears to be: "The methylenetetrahydrofolate reductase (MTHFR) 677CT polymorphism is associated with a reduced risk of some forms of cancer. The protective effect of this folate-related polymorphism is dependent on adequate folate status.
Cancer risk may be increased in individuals with the homozygous genotype for the MTHFR 677CT polymorphism who have low status of methyl-related nutrients including folate. Intake recommendations to potentially reduce cancer risk include substitution of low folate foods with folate-dense fruits and vegetables.
And, "Compared with 677CC
individuals with high folate intake, elevation of breast cancer risk was most pronounced among 677TT
women who consumed the lowest levels of dietary folate (OR, 1.83; 95% CI, 1.13-2.96) or total folate intake."http://cancerres.aacrjournals.org/cg...full/65/4/1606
"In this study we investigated how one particular form of the MTHFR gene polymorphism, 1298A>C, effects cancer risk and how it may convey its effect through either the coexistence of the second known polymorphism, 677C>T, or from a different mechanism."
"Methylenetetrahydrofolate reductase (MTHFR) balances the pool of folate co-enzymes in one-carbon metabolism for DNA synthesis and methylation, both implicated in carcinogenesis."
"The associations between dietary intakes of folate, vitamin B12, vitamin B6, or methionine and risk of adenomas showed consistent patterns dependent upon MTHFR genotype.
These trends were more pronounced among individuals over age 60, resulting in a 3–6-fold increase for low intakes of folate, B12, and B6. In conclusion, nutrients involved in the MTHFR metabolic pathway may modify the relationship between the MTHFR
C677T polymorphism and colorectal adenomas. Low intakes of folate, vitamin B12, and vitamin B6 increase risk among those (particularly the elderly) with the MTHFR TT genotype.
" http://cebp.aacrjournals.org/cgi/con...stract/8/8/659Our findings indicated that the MTHFR and MTRR polymorphisms were associated with individual susceptibility to breast cancer among postmenopausal women.http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
CONCLUSION: The present study indicates the significance of multiple low-penetrance alleles of functionally-related folate-metabolizing genes interactive with an estrogenic environment in breast
tumorigenesis.http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSumSO, ALL YOU MIDLINE MAMAS AND BABIES: EAT YOUR B-VITAMINS.
Interestingly, "We show that historically, the seasonal cycle of abundance of folate-rich foods may have regulated embryo viability by acting as a selection factor for a significant polymorphism within a gene encoding 5,10-methylenetetrahydrofolate reductase (677CT
"Over the past two decades evidence has been mounting for folate being an important nutrient in the prevention of cancer. Methyl-deplete diet and status, in particular, low folate intake and status has been positively associated with a number of cancers, including that colorectal, esophageal, breast, stomach, and cervical with colorectal cancer
being the most extensively studied. "
"Inadequate availability of nutrients involved in one-carbon metabolism may contribute to carcinogenesis via imbalances in the methylation and uracil incorporation in DNA that may manifest as aberrant gene expression and diminished chromosomal integrity.""We have observed protective associations for pancreatic cancer with greater dietary folate intake and serum folate and vitamin B6"
"Our results support the hypothesis that folate and vitamin B12, cofactors for their respective enzyme products
, may play a role in the carcinogenesis of these cancers."
http://dceg.cancer.gov/about/staff-bios/stolzenberg-solomon-rachaelhttp://jn.nutrition.org/cgi/content/...t/133/11/3748Shttp://cebp.aacrjournals.org/cgi/con...act/13/12/2071http://cebp.aacrjournals.org/cgi/con...tract/13/2/190http://www.pamelaegan.com/articles/f...iency_0001.htmMultivitamin Supplement Use and Risk of Breast Cancer: DiscussionIn addition, past use (of multivitamin supplement) for 5 or more years was significantly associated with risk of developing ER–PR– breast cancer and breast tumors without lymph node metastasis.
The associations between multivitamin use and breast cancer risk differed according to tumor size; a reduced risk was observed for ≤2-cm tumors but an increased risk for >2-cm tumors.In several large, prospective cohort and case-control studies, high intakes or blood levels of folate have been associated with reduced risk of breast cancer,
especially among women who regularly consume alcohol. In the Nurses' Health Study, plasma vitamin B6 levels were also inversely associated with risk of breast cancer.
In epidemiologic studies, including the Women's Health Study,
alcohol intake has been consistently associated with increased risk of breast cancer. Alcohol is known to antagonize folate and increases an individual's requirement for folate.
Alcohol is also suggested to be associated with an increased requirement for vitamin B6.
It has been suggested that folate may have a dual effect on carcinogenesis: folate may prevent tumor initiation when administrated early in carcinogenesis but promote tumor development when administrated later in carcinogenesis.[28-30]http://www.medscape.com/viewarticle/578426_3
In the Nurses' Health Study, an inverse association between intake of total folate, which includes folate from multivitamin supplements, and risk of breast cancer was present for mainly ER– breast cancer; such findings are consistent with the biologic data that folate plays an important role in the maintenance of normal DNA methylation, and aberrant methylation of the ER gene may be associated with the loss of ER expression in breast tumors.
Total vitamin D intake and vitamin D supplements were associated with reduced risk of breast cancer, but primarily among premenopausal women in the Women's Health Study and the Nurses' Health Study.http://aje.oxfordjournals.org/cgi/co...urcetype=HWCIThttp://www.medscape.com/viewarticle/578426Folacin (NOT folic acid) is a concurrent therapeutic agent with chemotherapy. http://www.sciencedaily.com/releases...0612082419.htmhttp://www.innvista.com/health/nutri...s/bfolacin.htmhttp://ww5.komen.org/ExternalNewsArt...x?newsID=38845
Some great sources of folate, include:
- Legumes (black beans, kidney beans, black-eyed peas)
- Leafy green veggies (spinach, broccoli)
- Fortified grains
Take care when cooking and storing these items though, heat and oxidation can destroy as much as half of the folate in foods.http://stanford.wellsphere.com/weigh...vention/414404http://www.encyclopedia.com/doc/1G1-174596896.html
Antacids and birth control pills inhibit folate bio-availability. http://www.nlm.nih.gov/medlineplus/d...nt-folate.htmlL-methyl folate is the most biologically active and usable form of supplemental folate. http://emedicine.medscape.com/article/200184-overview#section~workuphttp://www.mombu.com/medicine/skin-c...r-1904824.html
Folate metabolism plays an important role in carcinogenesis.
Compared with other cancer types, the role of polymorphic variants of the folate metabolism genes as risk factors for PBT has received comparatively little attention, and to our knowledge, only two studies have evaluated previously the role of variation in this pathway in development of glioma and meningioma.http://cebp.aacrjournals.org/cgi/content/full/17/5/1195
Causes and prevention of cancer. http://www.pubmedcentral.nih.gov/art...?artid=1470059http://www.pubmedcentral.nih.gov/pic...4&blobtype=pdf