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It's CANCER post #19 What was your exp w/ breast biopsy/cancer treatment? - Page 3

post #41 of 86
Originally Posted by uccomama View Post
Right, because there is absolutely no money in sodium bicarbonate for the pharmaceutical companies and they are the ones that control what gets researched because they are the ones with the money. Chemotherapy is a very lucrative business.
I can totally see how cheap cost can be a HUGE problem for doctors and pharmaceutical companies.
As I mentioned earlier I haven't looked into it yet. I, however, has been having a bump in my throat for a month or so and if it turns out to be a cancer I will DEFINITELY take a GOOD look into sodium bicarbonate. Simple logic does tell me that chemo and radiation very well might be a cure worse than the disease. Remember, radiation CAUSES cancer, why would it suddenly be safe when it comes to treating one?? Same goes for chemo…this is just what common sense tells me (but of course I’m yet to do a ton of research if things come to that)…
post #42 of 86
abomgardner417, I would do the same if I was in such a situation. I will keep you in my prayers as you begin this journey. The most important thing is you beating it.
post #43 of 86

Some of the posts on this thread quite frankly terrify me. If you are going to try things like sodium bicarbonate to cure cancer, make sure you read the double blind, peer reviewed, in vivo studies in the medical literature. Oh wait, there aren't any.
I just want to encourage reading the product insert for any chemotherapy agent which one considers having administered into their body. Look at the sample size of the research studies. Look at the actual research full text on PubMed, Medline, ncbi, science direct. When we reviewed the contraindications, age of the subjects, degree of tumor staging, side effects and outcomes for the chemo suggested for my mom, the studies were disturbing. Consider the likelihood of side effects of the treatments for the side effects. They say, that the malnutrition kills faster than the cancer.

There are many alternatives homeopathically, nutritionally to optimize health and immune system support.

I'd insist on specificity of cellular identification from the biopsy. There are a lot of RNA considerations which alter the choice of chemotherapy agents. The progressive alternatives are not available to the mainstream doctor. The clinical trials require different "acceptance" into their trials. Research, research, research. Be in charge of your health choices. The oncologists can only offer what they know: chemotherapeutic agents which are FDA approved. Which means the chemotherapy agent is now in "post-marketing research" on the public. Surgeons can only offer what they know: surgery.

Traditional Nutrition, Traditional Chinese Medicine, Homeopathy, Ayurvedic Medicine--- these have hundreds and thousands of years more research and experience than modern Westernized medicine. I was a critical care nurse for too many years to believe in the infallibility of the medical paradigm.

post #44 of 86
Originally Posted by Yulia_R View Post
I can totally see how cheap cost can be a HUGE problem for doctors and pharmaceutical companies.
As I mentioned earlier I haven't looked into it yet. I, however, has been having a bump in my throat for a month or so and if it turns out to be a cancer I will DEFINITELY take a GOOD look into sodium bicarbonate. Simple logic does tell me that chemo and radiation very well might be a cure worse than the disease. Remember, radiation CAUSES cancer, why would it suddenly be safe when it comes to treating one?? Same goes for chemo…this is just what common sense tells me (but of course I’m yet to do a ton of research if things come to that)…
Simple logic tells me that chemo and radiation, while no fun, are not worse than fungating tumors and wretched agonizing death, which has been what I have observed as the outcome of untreated or exclusively-"alternatively"-treated breast cancers, even here at MDC.

My own mom was successfully treated for breast cancer with surgery and chemotherapy when I was a child, and I am SO GRATEFUL to have her here with us almost 20 years later.
post #45 of 86
No experience to offer, I just wanted to offer you a . I've always liked your posts.

I guess I can offer that my great-grandmother had breast cancer and there wasn't any treatment at the time. She lived with it for over 20 years and died of old age at 85. ETA: I mean this to be inspiring, not to tell you not to get treatment or anything like that.
post #46 of 86
Um, you guys ... not my call to make, obviously, but wouldn't it be more appropriate to take the debate about Big Pharm and such to its own thread?
post #47 of 86
Thread Starter 
Originally Posted by Liquesce View Post
Um, you guys ... not my call to make, obviously, but wouldn't it be more appropriate to take the debate about Big Pharm and such to its own thread?
Thank you Liquesce! Reading through this I was thinking "HEY! This thread is about me, not a conventional/alternative argument!" But your post made me laugh and I realized no mothering thread is complete without some kind of debate, so I'm cool now!

Now please don't think that I don't value every single posters input. I am so thankful to have each and every one of you ladies in my corner, thinking about me, praying about me, sending me good vibes, great links, and lots of info to think about. So if you find some interesting info you think I may benefit from - no matter which side, please send the link.

On the other hand, the last thing I need right now is treatment bashing. I know I need to look at the cons of treatments and not be in denial about them. Yes, I know chemo will do a number (to put it as positively as possible) on my body, but I HAVE to embrace it, HAVE to start believing that it's meant to help me or else it won't work. Conversely, the majority of the conventional medical community thinks alternative treatments are a bunch of bunk, but I HAVE to believe that diet and supplements are going to help me fight this and maybe make chemo not so bad to go through.

I always said if I got cancer (of course I never believe I would!) I would never get chemo or radiation. Now that I'm in this place it's a totally different story! I just turned 32 less than two weeks ago and will not leave my boys - I can't afford not to be open to everything, conventional or not.

EFmom - thank you especially for sharing your chemo and wig experience - it's incredibly helpful. I'm sure I'll have lots more questions for you as I journey through this!

I have my CAT scan and EKG today, nasty Barium Sulfate to drink for the CAT. :Puke

Know that all your posts mean so much to me!
post #48 of 86
abomgardner- You have the best attitude! You're going to do great!
post #49 of 86
Originally Posted by abomgardner417 View Post

I have my CAT scan and EKG today, nasty Barium Sulfate to drink for the CAT. :Puke
Good luck with all the tests.

So, I went in for my various scans right after being dx'd. I was sitting in the waiting room, and these two little old ladies came over and sat down next to me. They were nuns, in their 80s, I'd guess. One of them was having GI problems and the other was there to keep her company.

The tech comes out and hands both of us a giant vat of the nasty Barium to drink. On the front of the container, there's a beautiful color picture of assorted fruits, and the label asserts that this is "fruit smoothie" flavor.

The nun and I begin to choke the stuff down. She looks over furtively at her companion to make sure she wasn't listening and then leans over and says to me in an Irish whisper, "Fruit Smoothie, my ass!" I almost spewed "fruit smoothie" all over the waiting room.
post #50 of 86
Yes, please start another thread if anyone wishes to have a (friendly) debate about allopathic medicine so abomgardner417 can get her specific questions answered.

Thank you kindly
post #51 of 86
You have a great attitude. That is so important. My sister was diagnosed with breast cancer in October (age 39). The cancer was removed surgically and then because of the type she had she did 3 courses of chemo and opted for a double mastectomy. She has her final reconstruction surgery next week.

No, the chemo was no picnic, but it wasn't anywhere as bad as she expected. Her biggest problem with the first 2 courses was it caused severe fatigue and depleted her immune system.

What helped her a lot was seeing a naturopath. It has been (and continues to be) very empowering for her to have some control over her health. She changed her diet completely, and takes a bunch of herbs and supplements. The guy she saw is a cancer survivor himself.

There are a lot of CDs out there for guided visualizations for the different aspects of treatment and making your body healthful yourself. You may find those helpful. Although I am all about that sort of thing, my sis was not prior to the diagnosis. They did help her.

Avail yourself of whatever help comes your way. Meals from friends? Great. The American Cancer Society has some good programs. They have mentors they can pair you with to help you navigate (they match you with someone who had the same sort of cancer I think), if that helps you. They also have this program to show you how to do wigs, scarves and makeup and can be really helpful in re: to helping you understand how to get your insurance to pay for wigs and how to choose them. Many of the volunteers are survivors themselves. I went to this meeting with my sis and the women felt a lot better at the end of the session. Really can seem like a minor thing, but looking healthy can go a long way to making you feel healthier.

Whatever you can do to take back some of the power is helpful (from my second hand experience FWTW). And you can definitely combine alternative modalities with Western med. The alternatives can really help with some of the side effects too.
post #52 of 86
Oh Mama, I'm so sorry you're dealing with this.

I was just diagnosed with melanoma a couple weeks ago and the waiting and testing and the questions and doubts and fears are so agonizing.

My thoughts and prayers are with you. I pray that whatever path you choose, you are at peace and your body responds with healing and fighting this cancer.

Thinking about you!
post #53 of 86
I had a biopsy done in a surgeon's office. It was not bad. It was a little shocking because I didn't go there expecting anything like that to be done that day. But otherwise not bad. She used a gun-type thing with a long needle. The lump was near my nipple, and she shot the needle in from up near my armpit. It really didn't hurt much - about like getting my ears pierced. And it wasn't really sore afterward, and I just needed a bandaid. I took some ibuprofen and had a soda on the way home and felt a bit less rattled.

I just read to the end of the thread.....I am hoping for perfect health for you !!!
post #54 of 86
Originally Posted by abomgardner417 View Post
I always said if I got cancer (of course I never believe I would!) I would never get chemo or radiation. Now that I'm in this place it's a totally different story! I just turned 32 less than two weeks ago and will not leave my boys - I can't afford not to be open to everything, conventional or not.
EXACTLY. It is easy for others to say what they'd do but when actually faced with cancer it is a world of difference. I think you are making great choices and have a fabulous attitude. I hope your treatment goes well and you are cancer free very soon.

A little story about my mom:
When she was 27 she had a pap done and the results showed dysplasia. She was young and had two young kids (8 and 4 yrs). She opted for a hysterectomy. She didn't care that some people thought it was radical or even unnecessary because all that mattered to her was avoiding cancer and living to be our mom. That was 22 years ago and she's doing awesome now. The same thing happened to her sister when she was 32 and she opted for a wait-and-see approach then ended up getting the hysterectomy with brief treatment because it had spread. That was 10 years ago and she is doing well.

Trust your instincts and take whatever treatment course you feel is best for you. YOU DO NOT NEED TO DEFEND YOUR TREATMENT CHOICES TO ANYONE! Period. Personally, I'd also opt for the researched-based proven treatment methods.
post #55 of 86
OP I would first like to say that I am really sorry about your diagnosis and I am sending you many good vibes.

I honestly can't believe people on here who have not been in the situation the OP is in can honestly say...treat it with a raw food diet and some arm and hammer??? This is a MOTHER, a DAUGHTER, a FRIEND, a PARTNER!!! She should do whatever is medically possible to stay alive because all this alternative stuff as treatment is NOT proven. As someone stated earlier there are no double blind peer reviewed studies for arm and hammer.

Now it would make more sense if some of you mentioned maybe doing medically PROVEN treatments ALONG with a good diet, exercise and a decrease in stress. Instead you tell a woman with treatable stage 1 breast cancer to not treat it. I honestly can't believe these posts are even still here because this information is dangerous.

Edited: None of you can even half understand what she is going through :.

My grandfather had very aggressive prostate cancer and he beat it twice with chemo and radiation and even though he has passed it wasn't from the cancer.

Goodluck to you abomgardner417
post #56 of 86
Originally Posted by Yulia_R View Post
I'm so sorry you have to deal with this (HUGS)

I haven't looked into this, but I did save the link just in case few months ago when I came across it. It talks about some powerful alternative method of beating cancer and also mentions that chemo is a "cure" worse than the disease


Sending lots of healing thoughts and vibes your way...
Give me another link. I can't stand Mercola.
post #57 of 86
Originally Posted by KatWrangler View Post
Give me another link. I can't stand Mercola.
Dr Tullio Simoncini -- a video from the Italian oncologist who pioneered the use of sodium bicarbonate in cancer treatment. BTW, sodium bicardonate is already used with certain chemotherapy drugs, (methotrexate treatment, I believe) to protect the kidneys, heart and nervous system from the toxic effects of the chemo. So what is the effective agent here, the chemo or the sodium bicarbonate? Personally, I don't think it is either, but out of respect for the choice that OP is making regarding her treatment, I will not express my personal views further.
post #58 of 86
MDC is not intended to be used for medical advice which the OP is clearly not asking for. The OP has asked for personal experiences, helpful websites, information, etc.

Please do not use this thread to complain about MDC's policies, posts or members. If you have specific concerns, please PM them to me rather than using this thread as a vehicle to vent. Please respect the OP and start a new thread if you wish to debate or discuss anything other than the information the OP has requested. Thanks!
post #59 of 86
"It has been known for almost 15 years that deregulated expression of the EGF receptor and ErbB2 contribute to the development and malignancy of breast cancer."

Overview of tyrosine kinase inhibitors in clinical breast cancer


Goal: tyrosine kinase inhibition.

***Comprehensive Natural Cancer treatments/herbs: http://www.cancercliniconline.com/SI...ANCERHERBS.htm

Thymoquinone inhibited cell proliferation and suppressed the activation of AKT and extracellular signal-regulated kinase. http://mct.aacrjournals.org/cgi/cont...tract/7/7/1789

Nigella sativa (lay overview)

*******Glycine max****
Glycine max "acting as a tyrosine kinase inhibitor "

Isoflavones (such as genistein & daidzein) and saponins isolated from Glycine max inhibit growth & spread of various cancers such as cancers of the breast, uterus, cervix, ovary, lung, stomach, colon, pancreas, liver, kidney, urinary bladder, prostate, testis, oral cavity, larynx, and thyroid.

Glycine max (seeds) is also effective in nasopharyngeal carcinoma, skin cancer, malignant lymphoma, rhabdomyosarcoma, neuroblastoma, malignant brain tumours and leukaemia. Isoflavones & saponins isolated from Glycine max possess wide ranging anticancer properties such as inhibition of cancer cell proliferation, promotion of cell differentiation and induction of apoptosis. Genistein works by blocking angiogenesis (formation of new blood vessel), acting as a tyrosine kinase inhibitor (the mechanism of action of many new cancer drugs) and inducing apoptosis.

http://en.wikipedia.org/wiki/Genistein (lay overview)

Insulin stimulates the tyrosine kinase activity of its receptor resulting in the tyrosine phosphorylation of pp185,



Nigella sativa (black seed oil)
Thymoquinone inhibited vascular endothelial growth factor–induced
extracellular signal-regulated kinase activation but showed no
inhibitory effects on vascular endothelial growth factor receptor 2
activation. Overall, our results indicate that thymoquinone inhibits
tumor angiogenesis and tumor growth and could be used as a potential
drug candidate for cancer therapy.
[Mol Cancer Ther 2008;7(7):1789–96]

The pharmacological investigations of the seed extracts reveal a broad spectrum of activities including immunopotentiation (5) and antihistaminic (6), antidiabetic (7), anti-hypertensive (8), anti-inflammatory (9), and antimicrobial activities (10). Many of these activities have been attributed to the quinone constituents of the seed (11,12).

Furthermore, blackseed preparations may have a cancer chemopreventive potential and may reduce the toxicity of standard antineoplastic drugs (13)

These results demonstrate either that the essential oil has an anti-metastatic activity in mice or that it inhibits or delays metastasis by rapid reduction of primary tumor volume at the site of induction.

On the other hand, to evaluate the side effects of these extracts, we tested their cytotoxicity toward normal human peripheral blood mononuclear cells. Interestingly, only minimal cytotoxicity was observed for all extracts.



Nigella is considered a BRM because studies show extracts from the seeds are toxic to cancer cells and, in mice, prevent blood cell toxicity caused by the anti-cancer drug cisplatin.1 The active components of nigella seeds are the volatile oils thymoquinoline and dithymoquinone, both of which inhibit tumor cells in laboratory experiments—even tumor cells resistant to anti-cancer drugs.2

N. sativa was tested in volunteers with a low helper T-cell to suppressor T-cell ratio. The results indicated an increase in the helper T-cell population in the experimental group. Further, the helper T-cell to suppressor T-cell ratio increased while the ratio within the control groups remain the same.

Nair et al. (1991) investigated the effects of N. sativa as potential protective agents against cisplatin-induced toxicity in mice. Some protective effects were shown by the use of N. sativa extracts.

N. sativa has been found to be most effective when administered at a dosage of 30 g per day, with an effective range of 20-40 g per day.

Nigella also stimulates the immune system, as shown in an experiment conducted with human lymphocytic white blood cells. Cells treated with nigella-seed proteins produced greater amounts of cytokines, specifically interleukin-1-beta and tumor necrosis factor alpha.4 How and if this is important to treating cancer is not yet established. http://www.newhope.com/nutritionscie..._00/cancer.cfm





glutathione is increased with black seed, inhibits tumors basically

The anti-oxidant glutathione is composed of the amino acids glycine, glutamic acid, and cysteine. Foods that increase glutathione levels in the body include cruciferous vegetables (Brussels sprouts, cauliflower, broccoli, cabbage, kale, bok choy, cress, mustard, horseradish, turnips, rutabagas, kohlrabi), avocados, ripe seeds of green beans, red beets, the herb rosemary, grape seed extract, bilberry extract, curcumin found in turmeric, whey protein powder, and Pycnogenol from pine bark. A food that is particularly high in glutathione precursers is whey made from milk.

Vitamin C elevates red blood cell glutathione in healthy adults. Fresh fruits and vegetables provide excellent levels of glutathione. Per serving, asparagus, avocadoes, asparagus, squash, okra, cauliflower, broccoli, potatoes, spinach, walnuts, garlic, and raw tomatoes have the highest glutathione content compared to other vegetables and are particularly rich dietary sources of glutathione.

The authors of this study concluded "it is not feasible to increase circulating glutathione to a clinically beneficial extent by the oral administrating of a single dose of 3 g of glutathione [supplement]."

Natural Foods That Boost Glutathione Levels: Asparagus is a leading source of glutathione. Foods like broccoli, avocado and spinach are also known to boost glutathione levels. Raw eggs, garlic and fresh unprocessed meats contain high levels of sulphur-containing amino acids and help to maintain optimal glutathione levels.

Undenatured Whey Protein has been shown in numerous scientific studies and clinical trials to optimize glutathione levels.

Curcumin (Turmeric) has been found to increase expression of the glutathione S-transferase and protect neurons exposed to oxidant stress.

Balloon Flower Root Changkil saponins (CKS) isolated from the roots of the Chinese herbal medicine, Platycodon grandiflorum. Balloon Flower Root or Jie Geng, have been found to increase intracellular glutathione (GSH) content and significantly reduce oxidative injury to liver cells, minimize cell death and lipid peroxidation.

Selenium is a co-factor for the enzyme glutathione peroxidase. (brazil nuts)

Milk Thistle is a Food Sources That Boost Glutathione Naturally!

glutathione levels cannot be increased to a clinically beneficial extent by orally ingesting a single dose of (supplemental) glutathione. (1) This is because glutathione is manufactured inside the cell, from its precursor amino acids, glycine, glutamate and cystine.

Hence food sources or supplements that increase glutathione must either provide the precursors of glutathione, or enhance its production by some other means.

The manufacture of glutathione in cells is limited by the levels of its sulphur-containing precursor amino acid, cysteine. Food sources for cysteine include poultry, yogurt, oats, wheat germ, egg yolks, red peppers, garlic, onions, broccoli, and Brussels sprouts.


Foods to help Phase 1 Detox:

Brown Ricehttp://www.gmhc.org/images/liver/carrot.gif
Melons and peppers
Tomatillos, papaya, plantains, carambola and guava

Foods to Help Phase Two Detoxification

Brazil Nuts
Papaya and Avocado

Foods for the General Health of the Liver
Soy Beans contain lecithin which helps the liver break down fats and helps reduce high cholesterol levels; lecithin also helps maintain healthy membranes around liver cells.

Cayenne Pepper
Caraway Seeds

long list of nigella sativa research


Nutritional value, functional properties and nutraceutical applications of black cumin (nigella sativa) (need full text) http://www3.interscience.wiley.com/j...89030/abstract

Thymoquinone, a component derived from the medial plant Nigella sativa, has been used for medical purposes for more than 2,000 years. Recent studies reported that thymoquinone exhibited inhibitory effects on cell proliferation of many cancer cell lines. http://mct.aacrjournals.org/cgi/cont...tract/7/7/1789

low toxicity: http://www.highbeam.com/doc/1G1-93210558.html

The pharmacological actions of the crude extracts of the seeds (and some of its active constituents, e.g. volatile oil and thymoquinone) that have been reported include protection against nephrotoxicity and hepatotoxicity induced by either disease or chemicals. The seeds/oil have antiinflammatory, analgesic, antipyretic, antimicrobial and antineoplastic activity. The oil decreases blood pressure and increases respiration. Treatment of rats with the seed extract for up to 12 weeks has been reported to induce changes in the haemogram that include an increase in both the packed cell volume (PCV) and haemoglobin (Hb), and a decrease in plasma concentrations of cholesterol, triglycerides and glucose.

The seeds are characterized by a very low degree of toxicity.


Restriction of tyrosine (Tyr) and phenylalanine (Phe) inhibited growth and metastasis of B16BL6 murine melanoma and arrested these cells in the G0-G1 phase of the cell cycle.

The natural tyrosine kinase inhibitor Genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells.








I researched anti-oxidants and chemotherapy at the hospital library. I found a bunch of research which *supports* the use of anti-oxidants alongside chemotherapy. Including the admonition to *include* anti-oxidants.

Genistein, a natural isoflavonoid phytoestrogen, is a strong inhibitor of protein tyrosine kinases. "Our results indicate that the natural isoflavone genistein antagonizes tumor cell growth through both cell-cycle arrest and induction of apoptosis and suggest that it could be a promising new agent in cancer therapy. "

"Dietary means were employed to reduce the intake of phenylalanine and tyrosine in patients with advanced malignant melanoma. The limitation of substrate, i.e., tyrosine, might, therefore, result in selective energy deprivation with consequent inhibition of tumor growth. In 3 of the 5 patients studied there was a clear relationship between the institution of the dietary regimen and the onset of regressive changes in the metastatic disease. There was a further direct correlation between the serum phenylalanine and tyrosine levels and the progression of the disease. This regimen, although beneficial with respect to some of the metastases and probably nutritionally sound, is cumbersome, complex and unpalatable, making its application difficult."

See top of "page 7": http://jem.rupress.org/cgi/reprint/137/1/1.pdf

Current medical research is focused on finding a patentable way to harness the benefits of Thymoquinone separate from the nigella sativa seeds. It is cheap to purchase Black seeds (nigella sativa) any middle eastern or Indian store. (maybe call first). It will be called either black seed or habbat-ul-baraka or kalonji (indian stores). They look similar to sesame seeds but black and they taste cumin(ish), or you could see if they have the oil. NOT black sesame seeds though. Must be nigella sativa (latin name).

I found them locally, easily. About $5 for a month supply. You could order from www.sweetsunnah.com so if you can wait it's better to do that. They're stuff is cold pressed, pure and you can get caps as well if you don't want to do oil/seeds.

Additionally, there is a lot of new information about the role of the MTHFR genetic alteration and folic acid supplemented associated cancers. The supplemented folic acid "fills up" the folate receptor sites so that folate can not be utilized by the body properly.

While googling everything cancer@ every medical research study on the net for my mom's pancreatic cancer, I found this research dated June 2007:


The researchers also say that they uncovered another interesting trend that some people who received these nutrients from multivitamin pills had an increased risk of developing the disease. According to the researchers, individuals who said they used multivitamins, and whose blood showed traces of these nutrients, had a 139 percent increased relative risk of developing pancreatic cancer.

Another separate study of 81,922 women and men, specific to folate from food sources.

CONCLUSION: Our results suggest that increased intake of folate from food sources, but not from supplements, may be associated with a reduced risk of pancreatic cancer.


It appears to be: "The methylenetetrahydrofolate reductase (MTHFR) 677CT polymorphism is associated with a reduced risk of some forms of cancer. The protective effect of this folate-related polymorphism is dependent on adequate folate status. Cancer risk may be increased in individuals with the homozygous genotype for the MTHFR 677CT polymorphism who have low status of methyl-related nutrients including folate. Intake recommendations to potentially reduce cancer risk include substitution of low folate foods with folate-dense fruits and vegetables."

And, "Compared with 677CC individuals with high folate intake, elevation of breast cancer risk was most pronounced among 677TT women who consumed the lowest levels of dietary folate (OR, 1.83; 95% CI, 1.13-2.96) or total folate intake."

"In this study we investigated how one particular form of the MTHFR gene polymorphism, 1298A>C, effects cancer risk and how it may convey its effect through either the coexistence of the second known polymorphism, 677C>T, or from a different mechanism."

Methylenetetrahydrofolate reductase (MTHFR) balances the pool of folate co-enzymes in one-carbon metabolism for DNA synthesis and methylation, both implicated in carcinogenesis."

The associations between dietary intakes of folate, vitamin B12, vitamin B6, or methionine and risk of adenomas showed consistent patterns dependent upon MTHFR genotype. These trends were more pronounced among individuals over age 60, resulting in a 3–6-fold increase for low intakes of folate, B12, and B6. In conclusion, nutrients involved in the MTHFR metabolic pathway may modify the relationship between the MTHFR C677T polymorphism and colorectal adenomas. Low intakes of folate, vitamin B12, and vitamin B6 increase risk among those (particularly the elderly) with the MTHFR TT genotype."

Our findings indicated that the MTHFR and MTRR polymorphisms were associated with individual susceptibility to breast cancer among postmenopausal women.

CONCLUSION: The present study indicates the significance of multiple low-penetrance alleles of functionally-related folate-metabolizing genes interactive with an estrogenic environment in breast



Interestingly, "We show that historically, the seasonal cycle of abundance of folate-rich foods may have regulated embryo viability by acting as a selection factor for a significant polymorphism within a gene encoding 5,10-methylenetetrahydrofolate reductase (677CT-MTHFR)."

"Over the past two decades evidence has been mounting for folate being an important nutrient in the prevention of cancer. Methyl-deplete diet and status, in particular, low folate intake and status has been positively associated with a number of cancers, including that colorectal, esophageal, breast, stomach, and cervical with colorectal cancer being the most extensively studied. "

"Inadequate availability of nutrients involved in one-carbon metabolism may contribute to carcinogenesis via imbalances in the methylation and uracil incorporation in DNA that may manifest as aberrant gene expression and diminished chromosomal integrity."

"We have observed protective associations for pancreatic cancer with greater dietary folate intake and serum folate and vitamin B6"

"Our results support the hypothesis that folate and vitamin B12, cofactors for their respective enzyme products, may play a role in the carcinogenesis of these cancers."

Multivitamin Supplement Use and Risk of Breast Cancer: Discussion
In addition, past use (of multivitamin supplement) for 5 or more years was significantly associated with risk of developing ER–PR– breast cancer and breast tumors without lymph node metastasis. The associations between multivitamin use and breast cancer risk differed according to tumor size; a reduced risk was observed for ≤2-cm tumors but an increased risk for >2-cm tumors.

In several large, prospective cohort and case-control studies,[25] high intakes or blood levels of folate have been associated with reduced risk of breast cancer, especially among women who regularly consume alcohol. In the Nurses' Health Study, plasma vitamin B6 levels were also inversely associated with risk of breast cancer.[9] In epidemiologic studies, including the Women's Health Study,[26] alcohol intake has been consistently associated with increased risk of breast cancer. Alcohol is known to antagonize folate and increases an individual's requirement for folate.[27] Alcohol is also suggested to be associated with an increased requirement for vitamin B6.[24]
It has been suggested that folate may have a dual effect on carcinogenesis: folate may prevent tumor initiation when administrated early in carcinogenesis but promote tumor development when administrated later in carcinogenesis.[28-30]


In the Nurses' Health Study, an inverse association between intake of total folate, which includes folate from multivitamin supplements, and risk of breast cancer was present for mainly ER– breast cancer; such findings are consistent with the biologic data that folate plays an important role in the maintenance of normal DNA methylation, and aberrant methylation of the ER gene may be associated with the loss of ER expression in breast tumors.

Total vitamin D intake and vitamin D supplements were associated with reduced risk of breast cancer, but primarily among premenopausal women in the Women's Health Study and the Nurses' Health Study.


Folacin (NOT folic acid) is a concurrent therapeutic agent with chemotherapy.

Some great sources of folate, include:
- Legumes (black beans, kidney beans, black-eyed peas)
- Fruits
- Vegetables
- Leafy green veggies (spinach, broccoli)
- Fortified grains
- Liver

Take care when cooking and storing these items though, heat and oxidation can destroy as much as half of the folate in foods.

Antacids and birth control pills inhibit folate bio-availability.

L-methyl folate is the most biologically active and usable form of supplemental folate.

Folate metabolism plays an important role in carcinogenesis.
Compared with other cancer types, the role of polymorphic variants of the folate metabolism genes as risk factors for PBT has received comparatively little attention, and to our knowledge, only two studies have evaluated previously the role of variation in this pathway in development of glioma and meningioma.

Causes and prevention of cancer. http://www.pubmedcentral.nih.gov/art...?artid=1470059

HTH, Pat
post #60 of 86
The NIH has a National Center for Complementary and Alternative Medicine, which was established to scientifically examine the safety and effectiveness of alternative treatments. See http://nccam.nih.gov/health/cancer/camcancer.htm
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