I use honey in bread, because it's been around the longest. I'm not too worried about putting some sugar (ie, honey) in my bread, since the yeast digests a lot of it.
Fructose isn't inherently evil, it's all about moderation. Since HFCS, we've suddenly become immoderate about our fructose use. Compare it with alcohol - your body can do well with a modest portion of red wine on occasion, but there's clearly a limit as to how much is good for a body. Fructose, in fruit, is just fine in moderation. Agave is modern and high in fructose, and therefore should be used with caution.
Aven