Originally Posted by whoMe
Cool, thanks! Folinate bypasses a bunch of the enzymes folic acid uses, but not MTHFR. So slightly better, but not much different than folic acid for someone like me.
I've been wondering for a while, is the folate vs folinate/folic acid issue only a problem for the 677C->T people? I've been reading the descriptions of the 1298A->C people as needing more, but at a later step--they can turn folic acid into active folate, can't they, but they just need a lot more incoming so their slow A->C conversion has enough to grab to recycle BH4? Am I reading the whole thing wrong?
And on another note, I've never really paid enough attention to this, but presumably different health problems are more associated with the double C->T gene vs the double A->C gene? Since the slowdown is in different parts of the cycle? Low methyl groups and the like are more an issue with the 677C->T genes, aren't they?
Sorry to throw this into the middle of chat, it's been churning around in the back of my mind for a while, but hasn't really percolated up to the top til I realized that DH's grandfather and aunt both had early strokes. And someone posted the Thorne article about the prevalence of MTHFR gene mutations in the Mexican-American community. And the funniest thing is, I just re-read it, and the study isn't saying that this gene is more common in the Mexican-American community, that's just who they happened to look at. But it caught my eye anyway.