It is one of my favorite books even though I only read it once and don't remember all that much of the plot I just remember it really made an impression on me. It set me off on a GGM kick that lasted all through high school and into college. I would also recommend Love in the Time of Cholera and Of Love and Other Demons if you want something of his that's different but similar in style and atmosphere.
100 Years of Solitude is really epic in a way that his other books aren't though.
I remember feeling as if I had endured 100 years of solitude by the time I finished it. I enjoyed Love in the Time of Cholera immensely, and some short stories too. For some reason, I never became hooked into the story in 100 Years of Solitude.
It's funny that you should mention it, because I was listening to an interview yesterday on the radio with an author who was inspired by GGM and that particular book. It almost made me think I should try to re-read it and figure out what I missed.
A while back there was a thread about naming your 5 favourite books.
100 years of solitude was on my top 5 list. I have read it several times over the years and enjoyed it each time. I liked Love in the Time of Cholera just as much. I like the way Gabriel Garcia Marquez weaves real life and magic together.