OP, I wish you good luck with whatever you decide. Given that nothing in life is risk-free, decisions like this are often hard on parents. The idea of possibly having some active role in that risk (via vaccination) versus letting nature take its course (often called omission bias) adds an emotional element that sometimes overshadows the issue. My best advice is to talk to someone you trust that has experience in this field. I wish you luck.
As for the relevant discussion about vaccines and diabetes - I'm assuming that the link is because more vaccine might aggravate the illness? I'm not sure the link is appropriate, but just in case I'm missing something (for instance, in case there's an underlying assumption that a vaccine would have caused the diabetes to begin with):
Originally Posted by ThereseReich
I don't think we need to start a new thread because the information that we're talking about is
relevant to her decision of whether or not to vaccinate. If vaccines cause diabetes, then she may not want to vaccinate in the future.
Here are the scientific studies:
Association between type 1 diabetes and Haemophilus influenzae type b vaccination:http://www.bmj.com/cgi/eletters/318/7192/1169
Hemophilus vaccine and increased IDDM, causal relationship likely
Journal of Pediatric Endocrinology and Metabolism
"Clustering of Cases of Type 1 Diabetes Mellitus Occurring 2-4 Years After Vaccination is Consistent with Clustering After Infections and Progression to Type 1 Diabetes Mellitus in Autoantibody Positive Individuals"http://www.freundpublishing.com/Jour...m/JPEM16_4.htm
"Baltimore, May 27, 2003: The prestigious peer reviewed journal, Journal of Pediatric Endocrinology and Metabolism published a study this week by Dr. J. Bart Classen, an immunologist at Classen Immunotherapies, and David Carey Classen, an infectious disease specialist at the University of Utah, providing support for a causal relationship between several common pediatric vaccines and the development of insulin dependent diabetes."http://www.vaccines.net/newpage113.htm
Therese, if you're going to try backing up your statements with evidence, it would be wise to check your sources first. Your first link, where you bolded the title "CAUSAL LINK LIKELY" is a commentary in response to another article that was published and which showed NO significant difference in their cohort study. The authors of the letter that you linked to, Classen and Classen, stated at THAT time that they had done their own study, NOT YET PUBLISHED, that suggested otherwise.
The second link is the link to their actual study, which was eventually published. It's the same study you're referring to in your third link. So, off the top, you're talking about ONE scientific study, not three. As for the authors, the lead investigator, J Bart Classen, and immunologist at CLASSEN IMMUNOTHERAPIES, has serious monetary conflicts of interest, namely his own company selling products to treat immune diseases, which also funded his study.
Even if their results are correct (though not replicated to date, as far as I've been able to find), there's a huge problem with the findings - he can't explain the mechanism by which a vaccine for Hib would cause diabetes. If it were truly an autoimmune response to the pathogen (live vaccine), surely there would be studies indicating that he virus (when contracted naturally) would also cause diabetes, but there are no studies to support this either. As far as I could find, there isn't a great explanation for his results, given by him, or elsewhere.
Just out of curiosity...why would you assume those were three unrelated links?
Oh, and in case you and the OP are interested, as this is really about what she should do in the case of her child:
Here's the link to the BMJ article (abstract - I'm assuming you have full access to the article?) Classen and Classen were debating: http://www.bmj.com/cgi/content/abstract/318/7192/1169
And here is a Danish cohort study that followed 700 000 children over 10 years (4 million life-years of the participants), that was unable to find this link between vaccine and diabetes onset (type 1). They also review the literature (including citing Classen and Classen) in their article, and suggest that there hasn't been great evidence beyond some animal models. In particular, they say:
"On the basis of ecologic evaluations, Classen and Classen have claimed that vaccination is associated with an increased risk of type 1 diabetes two to four years after vaccination.[8,9] We tested this hypothesis directly by examining data on individual subjects in a population-based cohort study. We found no support for the existence of a causal relation between type 1 diabetes and childhood vaccination overall or at any time after vaccination."Hviid, A; Stellfeld, M; Wohlfahrt, J; et al. Childhood vaccination and type 1 diabetes NEW ENGLAND JOURNAL OF MEDICINE, 350 (14): 1398-1404 APR 1 2004
Here's the reference to a nice review article that discusses the mechanistic hypothesis of the vaccine and type 1 diabetes - the references are in the article.2. Moylett, EH; Hanson, CI Mechanistic actions of the risks and adverse events associated with vaccine administration JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 114 (5): 1010-1020 NOV 2004
Here's another one.Cardwell, CR; Carson, DJ; Patterson, CC. No association between routinely recorded infections in early life and subsequent risk of childhood-onset Type 1 diabetes: a matched case-control study using the UK General Practice Research Database DIABETIC MEDICINE, 25 (3): 261-267 MAR 2008