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Winter IVF - Page 2

post #21 of 454
5terre, (((HUGS))). I know how much of a rollercoaster this can be. Hang in there! I am crossing my fingers for you.
post #22 of 454
MsGoodBuns - that's great advice. Just hang in there and follow directions.

Ayup. There is something I like about handing over the decision-making to someone else.

5Terre Hang in there. The hormones can really mess with you. I hope there's a fifth or more there for you.

Quote:
Originally Posted by wahine5 View Post


So tomorrow night I take the gonalF and the lupron. Should I wait in between shots or can I take one after the other?
My clinic gave me directions on mixing Gonal-F with the Luveris/Menopur...I don't know about how that goes with Lupron. Eventually, I'll be injecting the Gonal-F into the menopur/luveris vial, and then injecting the Ganirelix, swirling the whole thing, and then drawing it up with a third syringe to inject all three together. Fine by me, I don't even notice the Gonal-F syringe, but one shot is better than 3, right?


Have you guys done IM trigger shots in the past? Last month, I got instructions to do it SubQ but the package insert was all "For IM use ONLY" so I went with the clinic's directions.

In the past, my old RE and my OBGYN had the nurse give me the shot IM 24 hours before the IUI, but this RE is had me do it SubQ 36 hours before IUI, and this time around, 36 hours, SubQ before the retrieval. Thoughts?


I'm feeling a little better about this, getting into the swing of things a bit. I need to get some outside time soon, but it's so cold out there, I've been hibernating in my bed watching TV all weekend.

I still don't really believe this is going to work, but I think that's just the ugly you-don't-deserve-this voices in the back of my brain.

There's a little anxiety going on with my donor. He's explaining this whole thing to his parents and sibling over the holidays and it hasn't been going so well. Somewhere in the pit of my stomach is a fear that they will convince him to back out and I'll be stuck with a belly full of eggs and no sperm in sight.

I'm sure this is all just pre-IVF jitters, I'm just stuck in this-can't-be-happening-so-smoothly mode.

Shot # 2 tonight. . . .
post #23 of 454
Quote:
Originally Posted by wahine5 View Post

MOMTOALEXIS: My RE uses the progesterone suppositories. I think for the 1st trimester. Does this sound right? Thats pretty long.
Wahine - sorry, can't help with Lupron, I've never taken it.

As for the progesterone, yeah, that's about right. It is pretty long because the corpus luteum cyst would typically produce progesterone (p4), but with IVF the cyst is disrupted so it doesn't produce p4 properly, and with FET or donor egg recipient, there is no cyst to produce p4.

This continues throughout the first trimester, and then the placenta takes over p4 production, so with IVF, we have to mimic that same hormonal support exogenously.

Hope that helps. . . I've taken the compounded suppositories in the past, from a local compounding pharmacy my old RE used, they were solid in the fridge, but once at body temp they became this gross, oozey, oogey creamy goo. 3X/day with that. Fun times. It made me insanely overheated and constantly hot, though it was June/July/August in Toronto when I did those cycles, so it's gross and hot anyway.

They're shaped like bullets, so I called them c**t rockets. It was the only way I could deal with them.


I'm taking endometrin this time around, my understanding is that it's a pill taken as a suppository, so it's less messy and gross, but I don't actually know yet.
post #24 of 454
FtMPapa, I have a donor here in Boston who is willing to travel some in MA to donate. He's donated to several women in New England, and many have become pg. I didn't, but it was probably b/c of my eggs, not his swimmers. If you want me to hook you up, PM me with your name and number, and I'll pass them along to him.
post #25 of 454
Quote:
Originally Posted by msgoodbuns View Post
FtMPapa, I have a donor here in Boston who is willing to travel some in MA to donate. He's donated to several women in New England, and many have become pg. I didn't, but it was probably b/c of my eggs, not his swimmers. If you want me to hook you up, PM me with your name and number, and I'll pass them along to him.
Nope, but thanks. I am not letting my anxiety about my donor mean anything. I worry about him and his feelings, since I've been at this a lot longer than he has and have experienced more set backs. I have a tougher skin, and I worry that his relentless optimism is setting him up for huge disappointment and hurt.

I haven't told him about how complicated the insurance was, or about the details with the first clinic that wouldn't treat me, because I don't want to make this hard for him. He knows the gist of it, but it wasn't him I was calling every time I got more news, you know?

I mean, his role is not to be my partner, he is a source of support, but I have friends whose role it is to support me 100%, whereas his role is to provide sperm and occasional support, and my role is to provide him with information.

It's complicated. And he is my 100% preferred option, but realistically, if things don't work out with him, I'm burnt out on KDs and I'll probably go back to anonymous, since it's so easy.

He really hasn't given me any sense that he's any less than 100% on board, it's just my doomsday worst case scenario spiral spinning out of control.
post #26 of 454
Thread Starter 
Hey everyone. Thing were busy here this weekend. Dh, dd, and I just returned from an upstate ny vacation. My in-laws have a cabin up there and since they have gotten older they don't use it anymore and have handed it over to us. We try to go as much as possible, its so tranquil and peaceful so I wanted to go relax before I start stimming.

msgoodbuns-Sorry to hear you were so sick. I'm not sure about that being the norm because I had really bad OHSS so I was in pain everyday for a couple weeks till it went away, since I wasn't preggo it went away pretty quickly. Hope your feeling back to yourself by now.

FtMPapa-I think everything will be fine. Your donor seems on board and I don't think anyone will change his mind. It's a big decision and I think he wouldn't of agreed to it if he had any second thoughts.
I also mixed my meds last year and it was great to do one shot instead of 3, that always a good thing. Oh and always follow the clinics instructions, there were some shots that only said IM but clinic told me do it SQ. Sometimes we drive ourselves nuts but in the end they know whats best, well that's what I tell myself anyway. I'm a nurse so of course I never agree with docs.

5terre-Hoping for you that more follies catch up. Hopefully with your frozen and fresh you will make it to transfer. This is such a rollercoaster and we are all very strong women for what we do and no one can appreciate that but ourselves. My family and friends will never understand how bad I want this and what I'm willing to sacrifice to get it. Hang in there and I'll be praying for you. Your right my RE always tells me PIO shots are better thats why he never wants to switch to suppositories.

wahine5-You can give yourself the shots at the same time, but in different spots. It's easier to get it over with at once I think. Good luck you will do great.

AFM-I'm in cranky BCP world and can't wait to be done. I'm trying to be calm but just flipped on dh because he made a mess in the basement with all his tools and new stuff he got for x-mas. Oh well he'll get over it. I shut myself in the room but everyone seems to find me, even the cat is scratching at the door. lol. Only 2 more days of BCP and then I'll have no excuse for being cranky. Hope everyone is doing well and treating themselves good.
post #27 of 454
One or two?
I've been obsessing over this. I don't think I would ever regret having two babies, and back when I thought I had more or less unlimited IVF attempts, I thought single embryo transfer. Now, I'm starting to think double embryo transfer, since this may well be my only shot at IVF (at least until August....when I might be able to do another fresh cycle, with insurance coverage, which is a long time to sit out, for me).

I think I would always wonder "what if I had transferred two?" if this ends in a BFN and I only transferred one.

I feel like I can assume that I will have at least two embryos to transfer. Maybe that's dangerous thinking, but I'm not doing PGD, and I had six follicles on 150 iu of Gonal-F for six days, though my E2 levels were low, and this time around I'm starting out on 225 IU, and it's only day 2 of stims and I can already feel my ovaries singing to me about something.

I think I'm a fairly fast responder, in other words...but I don't really know.

Anyone know how many days of stims is typical? My clinic told me to count on 12 to 14, but it doesn't add up with the medication I have ordered. I think I'm way over-ordered on the Luveris, I have ten shots, and on the Ganirelix, I have five, and I'm under on the Gonal-F with eight shots, assuming I keep the current dose. IVF on a tight, tight budget is the pits.

Anyone know if I should expect to go up or down on the Gonal-F? Or could it really go either way? I want some certainty. I should probably just order two of the 450 IU pens so at least I won't get stuck with an opened, expiring pen I can't do anything with in the future.
post #28 of 454
Quote:
Originally Posted by MOMTOALEXIS View Post
AFM-I'm in cranky BCP world and can't wait to be done. I'm trying to be calm but just flipped on dh because he made a mess in the basement with all his tools and new stuff he got for x-mas. Oh well he'll get over it. I shut myself in the room but everyone seems to find me, even the cat is scratching at the door. lol. Only 2 more days of BCP and then I'll have no excuse for being cranky. Hope everyone is doing well and treating themselves good.
BCP is the worst, I've had to do two cycles of it, one just last month and one in the summer, of all the drugs and things I've tried, BCP and Clomid in July were the absolute pits. They made me CRAZY.

Though, I think I am seeing some crazymaking emotional effects from the Gonal-F this time around, I didn't have any last time around.
post #29 of 454
Quote:
Originally Posted by FtMPapa View Post

They're shaped like bullets, so I called them c**t rockets. It was the only way I could deal with them.
This is right up there with calling the internal ultrasound wand a "dildo cam".

As for Gonal F, I have had my doses both increased AND decreased mid-cycle.

MOMTOALEXIS and everyone else wacked out on hormones. It is so, so hard. Why not just plan to hide in the bathroom before anyone really annoys you? Cause you know it's gonna happen. For me, it was the suppression drugs that really turned my dh into an a$$.... Or was it me?
post #30 of 454
FtMPapa: OMG... You crack me up... The progesterone suppositories sound incredibly disgusting. But if they work, then it's OK. I ordered 8 days worth of the gonal-F. I had no idea they increase or decrease mid cycle. I don't think they'll increase me. I'm on 600 iu. That sounds soo high compared to yours. I think the RE thinks I will be a poor responder. I don't know what to think.
How are you feeling today? You were sounding sad last night. I hope you're more positive today. I'm really trying to think very positive. As for 1 or 2, it will definitely be at least 2 (or more) if they think it necessary. This is are only shot.... We can't afford another. I think if I had the choice, I would do one at a time. Then again, I don't know. The choice if kind of being made for me.

crazyrunningmama: I have loaded up on veggies, prune juice and gatorade. I will not get constipated .

MOMTOALEXIS: The 2 days will go by quickly.... What's next after BCP? Well, you can move me to stims now. I just gave myself the gonalF injection.

5terre: How are you feeling? There is still time for the follies to get bigger, right?

I hope everybody has a great week. I'm off to work tomorrow. I have had some time off since Christmas. I'm really not looking forward to it. I feel like I'm going to be cranky and emotional. How soon should I expect feeling these emotions? I feel like I already lashed out at DH today. This was before the gonalF.
post #31 of 454
Quote:
Originally Posted by crazyrunningmama View Post
This is right up there with calling the internal ultrasound wand a "dildo cam".
post #32 of 454
Quote:
Originally Posted by wahine5 View Post
I had no idea they increase or decrease mid cycle...............

crazyrunningmama: I have loaded up on veggies, prune juice and gatorade. I will not get constipated .

I hope everybody has a great week. I'm off to work tomorrow. I have had some time off since Christmas. I'm really not looking forward to it. I feel like I'm going to be cranky and emotional. How soon should I expect feeling these emotions? I feel like I already lashed out at DH today. This was before the gonalF.
For two of my cycles (first and third), they kept my dose the same, for the second one, they increased the dose, then my estradial when too high and I had to "coast" with no meds for a couple of days. I think it's very common that they choose the right dose at the beginning and you stay there for all of your stimming, but that's why they monitor you, to see how you are responding so they can change if necessary. Good luck!!!

Also, glad you're ready to stay "regular", keep a close eye on it and take a stool softerner if you have to (discuss with a nurse at your clinic first, of course).

And regarding emotions, that sneaks up on you as well. I thought I was "fine" until I flipped my noodle at some rude man at the library. Embarassing!!! I think I was just on suppression at that point, too! Take it very very easy on yourself, do not put yourself into challenging situations, avoid anyone or anything triggering or stressful. y'all!!! I'll shut up now, it's not my thread (repeats to self....)
post #33 of 454
So I have a question, which may betray my ignorance about how all this stuff works. I'm on day four of estrogen, just starting the first of two cycles of estrogen with progesterone added a few weeks later to "prep" my body for IVF. And I feel bloated and my abdomen feels kind of tender, like when you have to pee really badly.

It's not really painful but...what gives? I did notice a whole hella CM just now, too. To recap -- I don't get periods, pretty much ever, so maybe I'm just not used to what normal hormones do to a woman's body every month.

Could this be a mild form of OHSS? Can you get that on just estrogen, and this early in the game?

If it gets worse I'll definitely call the clinic, but it's more "interesting" than concerning at this point.
post #34 of 454
New Mama:
Are you on BCP? Those symptoms sound like pretty typical something-is-messing-with-my-hormones-symptoms, sounds totally normal.

Increased CM, especially EWCM is definitely a sign of higher estrogen. My sex drive goes way up, too. Also, I've noticed that I have a stonger body odor when I'm on hormones. Typically, I don't really smell a whole lot, like ever, because I have really low hormone levels, but when I was on BCP, I was standing in line somewhere and I was like "Woah, that woman behind me has BO, dude." And I looked and there was no one there. Just me and my stink lines.

Expect all kinds of wackiness as they mess around with things. Unfortunately, I haven't yet figured out how to *do* anything about it, just deal with it as best you can.

Wahine - 600 iu/day is a HUGE dose. Wow. I will not complain anymore about how much freakin' $$$ this is costing me. Are you just doing Gonal-F or are you doing menopur/luveris, too? I hear the luveris/menopur, they're apparently more or less the same thing, helps with the stims as you get further in, but I really don't know much about the combinations of drugs.




Thanks for checkin' in folks, I'm Ok. Borderline but OK. I am eager for my first ultrasound so I can see how many follicles there are. I'm waiting for a close friend to give birth any minute, and she's a fellow longtime TTCer, though without the huge interventions I've been through, so she's allowed and she also understands how I'm feeling about all this stuff.

My therapist is away next week, and I'm about to max my insurance coverage for therapy visits, besides. (I used to have really good health insurance, but they gutted it with recent budget cut backs by imposing all these ridiculously low limits, so we still have the same coverage, just not as much of it!)

Most of my meds are showing up tomorrow, hopefully, so I'll be cleaning my house and waiting for that nice guy from UPS. And my first ultrasound is Weds, I can't believe they made me wait so long! This is taking forever.

I also feel a little alienated from my clinic, I talk to my nurse every few days, and to the insurance person several times a week, but I haven't talked to my doctor in two months and I'm sure I won't until the day of the egg retrieval. I'm doing my monitoring at a local OBGYN, two hours away. I'd feel better about it if I were going in to the clinic every day, but I'm glad to not be driving 4 hrs round trip for each appointment.

Last totally paranoid crazythoughts: I hate the Gonal-F pen. tonight, I noticed that I should have used 675 IU of 900, or I should be 3/4 of the way through the pen, with one shot left for tomorrow night, but it doesn't seem like the level of the liquid is going down much. I had a full extra 150 IU in my last pen, and it's likely this one has extra, but it really looks like I've used less than 1/4 so I'm worried I'm not getting the right dose. ARGH!!!!! At least with a needle and syringe I would KNOW I got it, right? If I ever have to do this again, I'm getting the vial instead of the pen.

I don't trust the pen, it's too gimmicky.
post #35 of 454
Thread Starter 
New Mama- I haven't been on that protocol so not too sure of the side effects. But of course any of these meds we are given is messing with our hormones. Hope you feel better soon and never be afraid to give a call to the Re, it's always better to be safe than sorry.

FtMPapa-I wouldn't worry too much about the pen. I remember my last cycle everyone thought the same way as you and everyone agreed there is a lot extra in each pen. I'm sure your doing a great job, but you are right the pens are the worst. My Re does follistim but I think the pen works basically the same way as Gonal-F.

Hope everyone is good. Doing the overnight shift tonight and the ER is packed with patients. Just took a lil break to check in with everyone.
post #36 of 454
crazyrunningmama: thanks for all the info
Another question.... Is it OK to have a glass of wine with dinner while on stims? I didn't get a chance to ask the RE.

New Mama: What is CM?

FtMPapa: I was actually bummed out I didn't get the pen. It looked easier, but now I see that it's not. I'm sure you're doing it right. I'm only on the GonalF. Did you get the meds? What other meds are coming? Wow, your clinic is far. How often do you have to go there? Mine is on the way to work.

MOMTOALEXIS: Hope your night gets a little easier.

5Terre: How often should I use the Anji meditation? How are you?

I go in for my u/s tomorrow and to discuss PGD. Wish me luck, Ladies.
post #37 of 454
CM = cervical mucus.

Thanks, guys. I guess I'm on a birth-control pill-like protocol, except it's separate estrogen and progesterone pills.
post #38 of 454
Quote:
Originally Posted by wahine5 View Post
FtMPapa: I was actually bummed out I didn't get the pen. It looked easier, but now I see that it's not. I'm sure you're doing it right. I'm only on the GonalF. Did you get the meds? What other meds are coming? Wow, your clinic is far. How often do you have to go there? Mine is on the way to work.
My other meds are showing up today, I am obsessively package-tracking on UPS.com, which shows they're on a truck heading toward me and they'll be here any minute.

Luckily, I don't have to go to the clinic very often. I went for my initial consult two months ago, and in the next couple of weeks I'm going for the ER, and for the transfer, and that's it.

We did the semen analysis, and all the bloodwork at local labs, I do all my ultrasounds at a local OBGYN and the bloodwork at the hospital (both about 2 miles from my house and on the way to everywhere) and then I get phone call in the afternoon from the nurse.

This clinic is further from my house than the one 30 minutes down the highway, but in some ways it's easier taking a half day or the day off to drive two hours, but getting all the monitoring a five minute drive away. Actually, I think it works out to be more convenient overall.

I'm still bummed that the local clinic treated me so poorly - it's an unfolding story, I'm still working with them to figure out what's going on, but I had a consult with them in September and then they started behaving really poorly and screwed up my October cycle all on their own. I can't really go into details, but it's really ugly.


Good luck with your u/s and consult today! for good news.

My ovaries feel like they're the size of grapefruits already. I swear I can feel the follies bouncing around in there. 24 hours 'til my first u/s....the countdown begins!
post #39 of 454
So my RE just called with the results of bloodwork I had done last week. My TSH is 20, though my FT4 is within normal range. He called it subclinical hypothyroidism and wants to put me on 50mg of Synthroid. Sigh.

I do have a regular RE I was working with who was monitering my wonky thyroid levels, but I'd gone on Iodoral since last seeing her and had hoped that this was the "natural" thing my body was lacking and things would even out. I guess I'll go back to her (if I can get in...the earliest appointment they have is May, but I put a call in to her so I'm hoping she'll fit me in sooner) and we'll work something out.
post #40 of 454
Quote:
Originally Posted by wahine5 View Post
crazyrunningmama: thanks for all the info
Another question.... Is it OK to have a glass of wine with dinner while on stims? I didn't get a chance to ask the RE.

New Mama: What is CM?
Okay, obviously still stalking. Short answer on the wine: no. I have heard about studies or maybe just one study that found that consuming alcohol during a cycle lessens your chances of success. Not worth the risk in my opinion, even if the RE says it's probably okay.

CM = cervical mucous ie. goop "down there".


Continued everyone!!!
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