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Pertussis studies - Jamie Murphy's book

post #1 of 5
Thread Starter 
Is anyone familiar with the whole gamet of whooping cough studies? (which ones were performed well by no bias parties, results, etc..)

I read "What every parent should know about Childhood immunization" by Jamie Murphy and was floored by the chapter on whooping cough. It references studies that I never came across before (maybe I was just out of the loop).

From my understanding of the Cleveland, Ohio 1394-1936 & Great Britian 1942-1978 studies, they showed that pertussis infected both DTP vaxed and unvaxed children equally.
But then when the Binghampton, NY 1939-1940 study says that unvaxed children are more susceptible to pertussis. Murphy's arguement was that these were misleading. Based on the results of the Cleveland/GB studies. But should they have been evaluated seperatly?

If someone is familiar with these studies (or other ones), I'd love to hear their thoughts. I would love to believe that the pertussis vaccination does not prevent any infection (so I don't feel as guilty) but am having a hard time buying Murphy's arguements.
post #2 of 5
You might find this Inside Vaccines' article on Pertussis interesting.
post #3 of 5
Thread Starter 
Quote:
Originally Posted by Gitti View Post
You might find this Inside Vaccines' article on Pertussis interesting.
Thanks!
I actually just reread that page this week trying to figure out how well the vaccination actual works at preventing the symptoms.
post #4 of 5
I have not read those studies you ask about but I'm curious as to how the researchers determined infection. I'm wondering if they were actually doing cultures or if they were going by clinical case definition alone.

Because case definitions & lab criteria change over time, cases back then might not be classified as cases today. We had an interesting discussion about that once.
post #5 of 5
Thread Starter 
Thanks amnesiac!
Great point!
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