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Study shows late intro of solids increase incidence of celiac?

post #1 of 22
Thread Starter 
My ped actually said this yesterday, that there was a study showing that when intro of solids went from 4 mo to 6 mo, the incidence of celiac increased, and therefore I should start introducing gluten-containing cereals at 4 mos (he's 3 1/2).

Now, I really have no desire to start solids before he's ready, and even less to start with cereals, but I'm wondering if anyone else has heard this and has any info?
post #2 of 22
Sounds suspicious to me. My ped said to introduce solids between 4-9 months to decrease the risk of diabetes, but she personally recommended waiting till 6 months.
post #3 of 22
Yes, I remember reading that paper a few years ago. Starting solids after 7 months is linked with gluten intolerance.
post #4 of 22
I can't find the study I remember reading, but I did find this on PubMed. I didn't read it (we're having bedtime "issues" here tonight so I'm short on time!) but it might cover what you're asking about.

http://www.ncbi.nlm.nih.gov/pubmed/1...&ordinalpos=10

It's a great resource, BTW... I look up all sorts of questions on PubMed. I typed in infant solids and got over 700 results.
post #5 of 22
Just thinking about this makes me wonder why so many people nowadays are celic...or have gluten sensitivities..... yet most everyone in that generation was fed cereal early...and encouraged to eat cereal in bottles with the tops cut off. I know that was more then true for my husband.
Although I haven't read that study or heard anything about it before now....I am seriously skeptical....just based on my own interactions with celiacs and other gluten intolerant people.
tricia
post #6 of 22
That seems strange to me. I think they go back and forth on when to introduce peanuts, too, especially in people who are genetically prone to allergy. Sometimes they say early, sometimes they say late.

My experience with ds, was that it was plain he couldn't handle gluten as early as a few weeks old. It would bother him horribly when I ate it. He still can't handle much, although he can have a little bit here and there now without a huge problem. I didn't give it to him until he was much older because I knew it affected him. I wonder if the study took that sort of thing into account. It would appear that starting late caused his intolerance, when really we started late BECAUSE he had an intolerance.
post #7 of 22
Quote:
Originally Posted by Triciabn View Post
Just thinking about this makes me wonder why so many people nowadays are celic...or have gluten sensitivities..... yet most everyone in that generation was fed cereal early...and encouraged to eat cereal in bottles with the tops cut off. I know that was more then true for my husband.
Although I haven't read that study or heard anything about it before now....I am seriously skeptical....just based on my own interactions with celiacs and other gluten intolerant people.
tricia
There's a "window": starting solids before 4 months and after 7 is correlated to food allergies and intolerance. My guess is that the uptick in gluten allergies is partially a result of the time when mothers started solids at 3 weeks. I think there's probably also something to the fact that some people's systems just get overloaded by all the heavily processed, gluten-rich products that are part of the modern American diet. But I think actual research on that is still very much pending: that's just a theory that I've heard and it makes sense to me, based on the experiences of people I know.

Quote:
Originally Posted by Just1More View Post
That seems strange to me. I think they go back and forth on when to introduce peanuts, too, especially in people who are genetically prone to allergy. Sometimes they say early, sometimes they say late.

My experience with ds, was that it was plain he couldn't handle gluten as early as a few weeks old. It would bother him horribly when I ate it. He still can't handle much, although he can have a little bit here and there now without a huge problem. I didn't give it to him until he was much older because I knew it affected him. I wonder if the study took that sort of thing into account. It would appear that starting late caused his intolerance, when really we started late BECAUSE he had an intolerance.
Most allergies are totally 100% genetic, already there, not much you can do about it. Some are indeed It kind of bugs me that so much of the hand-wringing about when to start solids makes it seem like allergies are totally dependent on that, when in fact it's probably only pertinent in a minority of cases. It all just turns into another "no matter what happened, it's somehow the mother's fault" thing, which annoys me to no end.

You are right that the age to start peanuts and other risky allergens moves around. For a few years, it was suggested that people wait until at least 1, and many pediatricians said as late as age 3. However, this was based on a theory of immunology that turned out to be quite wrong. A friend who studies allergies said that the advice to put off allergens is basically a public health fiasco, because the research that's come out in the past few years shows that it probably made the problem worse. I probably wouldn't say "fiasco" (she's kind of an enthusiastic person, plus we were at a party), but the recent studies are pretty conclusive that starting nuts/eggs/etc when you start regular foods (between 4 and 7 months) is a better idea.

I dunno, I find all this really fascinating and I try to read everything I can on the subject. Both my husband and I have some weird and fairly severe allergies, and luckily it seems that both kids have escaped that. As I said, most of it is just genetic and luck of the draw (when people talk about genetics, it's important to remember that genetic doesn't necessarily mean hereditary... though obviously often it does) but I still worked overtime to figure out what were facts and what weren't when we started solids.
post #8 of 22
After reading the OP last night, I googled a bit and apparently theres studies as others have since posted, that indicate there is a 'window' in which solids should be introduced to avoid allergies/intolerances. That "window" appears to be 4-7 months - before that, your likely to see issues and afterwards too. Makes me think about starting solids a bit earlier than I did with DS1 last time around (he started ~7.5 months). That said, once he started soilds we didn't 'wait' on anything - he had bits of whatever we were eating from then on, whether that was fruits, veggies, grains, meats, nuts, dairy, etc.
post #9 of 22
I kind of wonder if people with food intolerances in their families (and therefore kids with a higher genetic likelihood of having allergies and other food intolerances) wait longer to introduce solids in the hopes that will help their kids, and that skews the statistics.
post #10 of 22
Quote:
Originally Posted by mamazee View Post
I kind of wonder if people with food intolerances in their families (and therefore kids with a higher genetic likelihood of having allergies and other food intolerances) wait longer to introduce solids in the hopes that will help their kids, and that skews the statistics.
I would think that this is one of the very first things that all these studies control for, as that was the medical advice for a while.
post #11 of 22
Quote:
Originally Posted by Triciabn View Post
Just thinking about this makes me wonder why so many people nowadays are celic...or have gluten sensitivities..... yet most everyone in that generation was fed cereal early...and encouraged to eat cereal in bottles with the tops cut off.
this has been my thinking recently, as well, as i explore my own possible gluten sensitivities.
post #12 of 22
I too agree pubmed is an amazing resource, as I use it daily for my own research (I'm finishing up my phd in biology). However, just reading the abstract may sometimes be misleading.... Unless you have access to the actual paper you should be weary of some results and conclusions stated in the abstract. I am by no means saying to never believe the abstract, but sometimes when you actually read the paper and evaluate the methods, sometimes their conclusions can be very long- reaching. I looked up that article, but unfortunately do not have access from home. I am very curious though, because the whole intro to solids and allergy debate is always going back and forth.... My ds is 7 mo and I have been trying solids for a month and he is denying any and all of my attempts to feed him, but if this is true, then I guess I'll try harder....
I agree that allergies are genetic, but most likely epigenetic, so the time of introduction could very well be a large factor...
post #13 of 22
Quote:
Originally Posted by Triciabn View Post
Just thinking about this makes me wonder why so many people nowadays are celic...or have gluten sensitivities..... yet most everyone in that generation was fed cereal early...and encouraged to eat cereal in bottles with the tops cut off. I know that was more then true for my husband.
Although I haven't read that study or heard anything about it before now....I am seriously skeptical....just based on my own interactions with celiacs and other gluten intolerant people.
tricia
Were they introduced before 4 months? Especially if it was introduced in a bottle?

Also, if it was in a bottle, they may not have been breastfed and there's another study showing that breastfeeding reduces celiac.
post #14 of 22
Quote:
Originally Posted by Icehockey18 View Post
I too agree pubmed is an amazing resource, as I use it daily for my own research (I'm finishing up my phd in biology). However, just reading the abstract may sometimes be misleading.... Unless you have access to the actual paper you should be weary of some results and conclusions stated in the abstract. I am by no means saying to never believe the abstract, but sometimes when you actually read the paper and evaluate the methods, sometimes their conclusions can be very long- reaching. I looked up that article, but unfortunately do not have access from home. I am very curious though, because the whole intro to solids and allergy debate is always going back and forth.... My ds is 7 mo and I have been trying solids for a month and he is denying any and all of my attempts to feed him, but if this is true, then I guess I'll try harder....
I agree that allergies are genetic, but most likely epigenetic, so the time of introduction could very well be a large factor...
Part of the discussion about the conclusion was that the amount of wheat might play a role in the increased allergy response after 7 months old. That a baby who starts grains later might be fed a lot more of them at once.

Oh, which would be another thing that could explain a higher incidence of celiac in a population that got cereal early, if the cereal was to move towards ending milk feeds by a young age, the baby would've gotten lots more cereal than a baby who was just being introduced to solids.
post #15 of 22
As a kiddo with Celiac (and no family history of Celiac), this is a topic near and dear to my heart. She was EBF until 6 months, then we did baby led solids, and she nursed till she was almost 4yo. As it was explained to us, Celiac disease is a "two part" condition... a person is genetically primed for Celiac but may not have any symptoms until there is a triggering event, generally something that aggravates the immune system while the person is also exposed to gluten. Our family is now gluten free so ds wont be getting gluten grains as part of his early exploration of solid foods, but dd2 (who actually refused most solid food until almost a year) has no gluten sensitivites.

My personal opinion is that a large part of the uptick is due in part to better testing (or at least easier, people are much more willing to take a blood test than an endoscopy) and another part is due to increased awareness on the part of family practice/pediatric care providers. Celiac disease is better known and more actively diagnosed as a result.

I agree with a pp about pubmed... it's a wonderful resource that more people should be aware of. But abstracts can be misleading, and without access to the full study (or a good grasp of the statistical tools being applied) the results may not mean what you think they mean (to borrow from Princess Bride )
post #16 of 22
Quote:
Originally Posted by wombatclay View Post
Our family is now gluten free so ds wont be getting gluten grains as part of his early exploration of solid foods, but dd2 (who actually refused most solid food until almost a year) has no gluten sensitivites.
Wombat, When do you plan to let Ds try gluten-containing foods? My 7 yo DD and I are gluten intolerant but do not have full-blown celiac and do not eat any gluten ... ever. (I feel just dreadful if I have any.) I am really concerned about when the best time to introduce my near 7 mo Ds to wheat/barley etc.

Just as an fyi (for those who may be unaware), gluten intolerance and celiac disease are not the same thing as an allergy to gluten. Celiac is a disease process that damages the lining of the small intestine such that nutrients from food are not properly absorbed into the body. People with a wheat or gluten allergy could also have Celiac, but the two don't necessarily go together. I say this b/c there is a lot of confusion about how to go about getting Dxed with allergy to gluten, vs. Celiac or gluten sensitivity. Celiac is best Dxed by a gastroenterologist and unfortunately the best way (although still not 100% failsafe) to be evaluated for CD is via biopsy of small intestine.

Here is a great link to some info (peer-reviewed, a study in Sweden) and timing of gluten and BFing and Celiac. It says that Bfing for a month after baby's first exposure to gluten may be key in at least delaying the timing of onset of celiac. This research is a little old (early 2000s, but still seems to be helpful.
http://www.celiac.ca/Articles/PAB%20...20feeding.html
post #17 of 22
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post #18 of 22
Quote:
Originally Posted by mamazee View Post
I kind of wonder if people with food intolerances in their families (and therefore kids with a higher genetic likelihood of having allergies and other food intolerances) wait longer to introduce solids in the hopes that will help their kids, and that skews the statistics.
This. Celiac is genetic, in fact DH and I were tested to see if we were "carriers" of Celiac when DD had a suspected gluten intolerance. We delayed solids until 7 months with DD2 (her choice) and she has a dairy allergy and a couple others. Delaying solids didn't cause her allergies, genetics did; I am allergic to tons of things so the poor thing is destined.
post #19 of 22
post #20 of 22
Penny4Them- We're not sure how we're going to introduce gluten to ds. DD1 was diagnosed when I was pregnant (blood test was positive, the gfree diet relieved the symptoms, we'll let her decide about the endoscopy when she is a bit older since there are no children's hospitals around here and at 4yo it would be a "big deal" for her). DD2 didn't show a sensitivity to gluten or full blown celiac based on the blood test, but the blood test isn't fool proof and it was just easier for me to make the whole house gfree. DD2 has sensory issues though so swapping out familiar foods was a slow process.

We do baby-led solids so generally the kiddos start out eating whatever the whole family is eating so I think ds will be gfree just by default. Since the blood test (and endoscopy) require exposure to gluten I suppose we'll introduce gluten grains maybe around a year? Just so we can get blood work done and know how vigilant we'll need to be in terms of socializing. At 4yo, dd1 knows what she can/can't eat and can articulate that pretty well. But with a crawling/toddling/mouthing everything/eat the other kiddo's snacks aged child I don't want to put up unnecessary boundaries to exploration or drive myself silly keeping him away from gluten if I don't have to.

(For those who fortunately haven't had to research Celiac, gluten comes in wheat, barley, and rye flavors and has to be avoided completely. Since it's not an allergy there often isn't an immediate sign that you've been exposed so by the time your child feels icky it's too late. And completely means that you can't share snacks since you don't know if the apple slices were cut with the same knife used to slice the gluten rich bread, or if the peanut butter jar was contaminated with gluten crumbs, or if barley malt was used by the manufacturer to add "crunch" to the otherwise innocent looking trail mix. You have to make sure your friend's table is scrubbed down before lunch since their child may have had playdough on it earlier. And so on... it's a pain with a preschooler but it would be a nightmare with a young toddler! )
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