Several years ago when I was browsing online for yard sale tips, I read recommendations that you shouldn't price by the table, but actually mark each item. People might not notice a sign and don't like to have to try to figure out what price you are looking for. Apparently people also shop better when everything is on display rather than in boxes.
That said, I don't see anything wrong with putting a bunch of frames in an oversize box for example (oversize so folks can look through without taking each item out), putting a big sign on the box that says in large, clear writing "ALL FRAMES $1" or whatever, and then just setting out a few of the nicest frames in front of the box to attract people over.
I'm a fan of making things simple. Yard sales can be a ton of work.
With things like clothing (those you don't sell on consignment) or books (a bit less than clothes) and CDs, I've heard it recommended that you don't bother trying to sell them individually. The CDs you might be able to take to a pawn shop, but anyway, apparently the recommendation is to bag and box things up in like groupings (such as women's dresses size 14, all varieties) and market these as a "buy a bag" type purchase. Say, $5 a bag or box. People respond pretty well to the possibility that they might find a few gems in a big bag which may also have some things that don't work out for their tastes, etc. Especially with music when people might not know all the artist names. As the seller too, I personally would rather haggle with a couple people over two boxes of books, say for 0-2 year olds, than spend my day haggling over every book. And a lot of folks go to sales to find items to resell or give to their church's childcare or to grandchildren or whatever, so these people will buy up stuff like this quickly, apparently.
It probably wouldn't work so well for things like scrapbooking supplies, and items for which you don't have one big group of like typed items. Plus, you want to have enough out on display and placed out individually that there are things to catch the eyes of potential shoppers and get them to stop. Just be strategic.
Whatever you do, just be sure to call and get a charity to come pick up the leftovers the very next day (or plan to pack it up right away yourself and take it in), or packing everything back up and moving it in and then finding time to take it back out might defeat your purpose. My last yard sale was probably ten years ago, and we actually just closed up shop at 1pm or whenever it was that traffic really slowed down but hadn't completely stopped, put up a big, bright sign saying "Everything free! Help yourself!" We left the yard sale signs up to help keep folks coming, and we even put a sign on our door that said "Please don't ring the bell. Just take it!" And then we went over to our friend's house for the rest of the afternoon. When we came back, a number of items were gone, we decided to keep everything as it was overnight. We lived in a college neighborhood, and overnight we heard college students rummaging around, getting a little silly, and wondered how bad it would be in the morning. What was left in the morning was a bit of a mess, but they had hauled off so much it made it worth it. We devoted that morning to loading the rest up and hauling it off, as well as taking down our signs. All-in-all, it worked out well.
Of course, you could always try my mom's approach. For a few years, she got into a stretch during which she got "famous" in her neighborhood for her "25 cent sales." She'd put up big signs saying "25 cent yard sale" and would literally sell each item for a quarter. People liked the simplicity of it, including my mom. Certainly there were plenty of items she could have sold for more money, but it always balanced out because she generally sold more than she would have otherwise. Of course, that became her little niche, so it may have been her regular sales that became the key to the success of the method. If you had bigger items to sell too, like couches and chairs, you could do a 25-25 sale, with every item either being 25 cents or $25. While it is possible you could earn more money, like I said, I think sometimes just getting things sold is the way to go when otherwise you are looking at just donating and getting things over with.
Of course, like someone said, getting your house sold faster would make you more money in the longrun, so if the yardsale thing is slowing you down, don't do it.
As for location, I am with the person who said the signs are more important than the location. I like signs on the same, matching *bright* color of posterboard so you can follow them and know you are headed where you intended. Arrows, days, and hours are most important. BIG SIGN=BIG, BOLD LETTERS (in black). Don't crowd it out with unecessary info. That said, on the signs that are being hung on the main streets, consider posting the street number and name under the arrow, as some folks will just plug it into a GPS or check it out on a map at that spot before trying to follow signs that may turn out unreliable.