Guess your genetics (Yasko related...) - Page 2

[tanyalynn]

There are two pancreatic supports...

This is the first....
http://www.holisticheal.com/special-...upplement.html
These are the strong ones...

The second is basically a pancreas glandular...
http://www.vitacost.com/NutriCology-...as-90-Capsules

The second is available multiple places, and I guess other brands are around too, but it's not terribly expensive.

[DevaMajka]

Thank you!

[tanyalynn]

to move some stuff from June 2010 Chat to here...

From mamafish9 from the last thread....
Quote:
Yasko uses three different things primarily for pancreatic support - her special enzyme blend, with lots of pancreatin. Then ground up pancreas - which I think is basically what the vitacost stuff would replace (it has pancreatic enzymes too, in the ground up pancreas, but likely lower concentrations - DS didn't have nearly the reaction to the ground up pancreas as he did to the enzymes). Then three, a list of supps to support the pancreas. Or you can cover off #2 and #3 in this compounded supp she puts together (linking to that so you can see the list of compounds she suggests - this is all related to a key mutation in the vitamin D receptor that impacts pancreatic function, and increases the need for vitamin D).

If you can take it, I'd start with an enzyme with straight up pancreatin for most direct impact on digestion - and then if that works, consider some broader pancreatic support on the theory that the pancreas does lots of things besides digesting, so general support is good if there is indicators of pancreatic weakness.

Best place to get an overview of her stuff is her Pathways to Recovery book, you can read most of it on google books.

Tanya getting clarification....

Okay, so #1 above is a specific blend of digestive enzymes with lots of pancreatin ($20 = 17 days of an adult taking 2/meal, 6/day... most people start lower dosages, with kids it's a whole lot lower)

#2 is just ground up pancreas (some digestive enzymes in that, generally good/supportive for the pancreas?) (a product like this Nutricology pancreas supp is about $9/mo)

#3 is to help eventually not need #1 and #2?
(haven't looked at this list or costs yet at all)

Do I have that at all right?

Shannon helping me understand....

Looks about right, Tanya. FWIW, I've just done the enzymes, plus lots of greens (for the K) and lots of connective tissue/gelatin (for the glycine/serene). And am making Rosemary my new favorite herb. I think most of the benefit I'm seeing has to do with dumping my old gut bacteria more than anything else. I think it must have been eating my food/vitamins.

I'm debating bringing ds in to the doctors office for this round of bloody poop I'm pretty sure they wouldn't be helpful on the allergy/die off front, but they could confirm blood and check for any major stuff. And there'd be a record that I brought him in, for better or for worse.

Cutting/pasting Deb twice because wow, we're bopping all over the place with questions and I was having trouble just keeping up on my 2nd re-read!

Yes on #1 and #2. #3 is in addition to #1, but replaces #2.

[tanyalynn]

Originally Posted by changingseasons View Post
Ok- what's the difference between the pancreatic enzymes and the pancreatin support?? The ones I'm ordering are enzymes, right?

Deb responding...

I think what you're getting is basically pancreatic extract. So lots of pancreatic enzymes, but not quite as concentrated as the straight pancreatin (which I think is just really isolated pancreatic enzymes). Since you can only do lamb, it's the best choice for you, LOL! Dr. Yasko's enzymes have pancreatin, and then a bit of other enzyme stuff, papaya, etc. But that's not where the power is, IMO, and just adds a bunch of other potential allergens.

Originally Posted by tanyalynn View Post
Okay, so #1 above is a specific blend of digestive enzymes with lots of pancreatin ($20 = 17 days of an adult taking 2/meal, 6/day... most people start lower dosages, with kids it's a whole lot lower)

#2 is just ground up pancreas (some digestive enzymes in that, generally good/supportive for the pancreas?) (a product like this Nutricology pancreas supp is about $9/mo)

#3 is to help eventually not need #1 and #2?
(haven't looked at this list or costs yet at all)

Do I have that at all right?

Deb answering in bold below
Yes on #1 and #2. #3 is in addition to #1, but replaces #2.


More info from Deb....

Yup, Yasko is very big on supporting organs, and supporting to bypass mutations, and then lots of other symptoms tend to resolve themselves. I don't like how she handles metals, but for a lot of other things, I think it's a really good approach.

Anther small example, DS' vitamin C need has cut in half in the last month (he had to be on 2000mg a day or he got a stuffy nose). So vitamin C got the job done, but it was just a bandaid on one symptom of poor methylation - now that he is methylating better, he doesn't need the vitamin C to handle the histamines.

We'll be rerunning his pee tests this month, so I should have very clear evidence of what differences have come from her supps (we ran the tests in mid March just before starting anything from her program, and we'll do them again in mid June, 3 months later, and after him being on most of what I think he needs based on his genetics).

[changingseasons]

subbing so I can come back and read later...

[mamafish9]

Tanya, you're my hero. Thank you for moving all that!! It seemed like it belonged in it's own thread, but I'm so used to just saying everything in chat.

[Koalamom]

subbing!

[tanyalynn]

Glad to help, Deb.

Well, I ordered last night, so I'll add us to the experiment.

DH: overweight, did well low-carb last fall but I didn't keep it up, would bet on insulin issues (either current or building),

me: weird digestive issues (bloating, weight gain, raw veggies not being digested well) for the past ~18 mos since I started the alpha lipoic acid

kids: fewer stomach aches for the past few months (I *think* I've got all their problematic foods out, always hoping they haven't developed new ones, I don't see a pattern) but still some stomach aches and generally touchy digestion (probably also related to me not making kimchee regularly... got that going now)

[mom61508]

I wonder...I've been trying to do green smoothies lately(I stopped awhile back because they were making me sick to my stomach) and unfortunately they're still making me sick to my stomach right after the first sip. I just can't get more than a sip down!

Could this have anything to do with what we are talking about???

[deditus]

Originally Posted by mom61508

I wonder...I've been trying to do green smoothies lately(I stopped awhile back because they were making me sick to my stomach) and unfortunately they're still making me sick to my stomach right after the first sip. I just can't get more than a sip down!

Could this have anything to do with what we are talking about???

Green smoothie issues for me were related to low stomach acid.

[mamafish9]

I thought you all might find this list interesting. It's the "very lite" version of the Yasko protocol I've put together for the rest of the family. We have some clues based on DS' genetics, and some is guesswork based on symptoms:

A, D, K2, C, minerals (we are on all these already)
B complex
special digestive enzymes (definitely for DH, trialing for DD, if good for her, I'll trial for me too, otherwise I assume DH is the source of the pancreatic related mutations in DS)
VDR/Fok compounded pancreatic support (#3 in Tanya's list above, for DH, and DD if the enzymes help her)
probiotics
hydroxy B12 (I figure my son's two tough MTRR mutations must come from somewhere, so we'll slowly increase amounts for all of us and watch for benefits - I'm guessing this may be where I've contributed, my side of the family has lots of autoimmune issues)
intrinsi B12/folate (this is a supplement on Dr. Yasko's site - intrinsic factor helps transport B12 out of the gut, and the folate is mthf folate - she suggests 1/4 of the tablet a day for dosing, so low dose, as basic methylation support for everyone, along with *some* B12 - 3-5mg is her base dose for most ASD kids, more if you have relevant mutations)
CBS compounded supp (it's a key support for 3 different mutations DS has, so odds are good we all have at least one, and there are some things in this compounded supp that we probably all need, and this is the cheapest way to get them)
low dose 5htp/st john's wort for me, and probably DD (DS has a gene mutation called MAO+, which is maternal inheritance - so I definitely have it, and DD may, symptoms say likely yes. It slows breakdown of serotonin, so you get high serotonin, then that feeds back and causes low serotonin - so you swing. The low dose 5htp - small doses several times a day is supposed to even out the swings, is working great for DS)
ora-adrenal (ground up adrenal gland - DS has a mutation that needs this, it kind of permanently elevates your body's stress level. Hair test suggests DH is the source - sodium low, potassium high. DD's hair test doesn't have this pattern, but she's my anxious kid, so I'm going to try this for her anyhow).

[waluso]

Mamafish - Would you mind linking to Yasko's genetic test again? I'm having a hard time finding it. Thanks!

[JaneS]

Oh thank you, no need to answer me in chat re: hydroxy b12.

Originally Posted by mamsfish9

ora-adrenal (ground up adrenal gland - DS has a mutation that needs this, it kind of permanently elevates your body's stress level. Hair test suggests DH is the source - sodium low, potassium high. DD's hair test doesn't have this pattern, but she's my anxious kid, so I'm going to try this for her anyhow).

I believe this means means low aldosterone and lots of celtic sea salt helps:
http://www.stopthethyroidmadness.com/aldosterone/

DS naturally eats tons of salt, I let him put it on himself, so I wonder if he just simply has the need. I haven't done the flashlight test on him but I failed it.

[tanyalynn]

Jane, it took me quite a while to realize that DD had adrenal issues. Sadly, it took extra stress last winter/early spring to really see it, as she went downhill for a while, but I think it was there low-level beforehand. I do the same with letting the kids salt things to taste for the same reason as you, to let them self-regulate since their needs may be atypical (well, typical in our family ).

[mamafish9]

Originally Posted by waluso

Mamafish - Would you mind linking to Yasko's genetic test again? I'm having a hard time finding it. Thanks!

http://www.holisticheal.com/health-t...enomic-testing

Originally Posted by JaneS

I believe this means means low aldosterone and lots of celtic sea salt helps:
http://www.stopthethyroidmadness.com/aldosterone/

DS naturally eats tons of salt, I let him put it on himself, so I wonder if he just simply has the need. I haven't done the flashlight test on him but I failed it.

Other way with this mutation - it raises angiotensin & then aldosterone, and that tends to retain sodium & dump potassium. Long term, if your cortisol runs down, it can switch to retaining potassium, dumping sodium, and I *think* that's when the sea salt can be helpful.

[mom61508]

Originally Posted by deditus

Green smoothie issues for me were related to low stomach acid.

Oh lovely

[tanyalynn]

Originally Posted by mamafish9

Other way with this mutation - it raises angiotensin & then aldosterone, and that tends to retain sodium & dump potassium. Long term, if your cortisol runs down, it can switch to retaining potassium, dumping sodium, and I *think* that's when the sea salt can be helpful.

Would people with this mutation be prone to high blood pressure, and be salt sensitive?

Could the answer to *everything* be here? (no, of course not, but this could be such a helpful link for some people, or some issues... totally looking forward to doing testing someday, hopefully we don't have a critical need to do it soon, i want to wait 5-10 years so it gets cheaper and tests more stuff.. so much cool stuff to know!)

[mamafish9]

Originally Posted by tanyalynn

Would people with this mutation be prone to high blood pressure, and be salt sensitive?

Could the answer to *everything* be here? (no, of course not, but this could be such a helpful link for some people, or some issues... totally looking forward to doing testing someday, hopefully we don't have a critical need to do it soon, i want to wait 5-10 years so it gets cheaper and tests more stuff.. so much cool stuff to know!)

Yes on high blood pressure. Don't know on salt, I can't remember reading anything about that, but it would make sense. I just searched the Yasko forums, she links craving salt to low aldosterone, or anemia (often induced by lead).

I do think the ability to customize supplements to genetics has the potential to be hugely helpful. And the cost is coming way down, Yasko's test used to be over $1100 just a year or two ago, now it's under $500, and testing more genes. I'd love to run it on the whole family, but for now we're putting the $$ on DS and guessing for the rest of us .

I also find it fascinating how many different health issues can be traced back in clear lines to some of these genetic mutations - it has helped tie DS and DH's health issues together around pancreatic function, which isn't a connection I would have made before. Or to see the threads of neurotransmitter swings for many family members, and to be able to pinpoint a couple of supps that could help with that.

[Theloose]

[Theloose]

Originally Posted by mamafish9

2) Pancreatic support. There are several gene mutations that can play into this, but what happens is that your pancreas is "slow" on several functions:

a) blood sugar regulation (mood swings, crashes when you don't eat, etc)
b) pancreatic enzymes (poor digestion, sometimes in non-obvious ways - DS had low amino acids on a pee test, even though he eats lots of protein - I never guessed he wasn't digesting protein well, it wasn't obvious from his poop!). Poor digestion = bad gut flora, so many people find this is a core underlying cause in the inability to permanently improve their gut
c) glutamate -> GABA conversion. This is a big one for many autistic kids, because glutamates are excitatory (wild, unfocused, non-sleeping kids), and GABA is calming (focus, language, stability, better sleep)

As a data point, a) was definitely me until the past year or two when I've really discovered high fat/lowish carb. b) I never would have guessed at poor digestion (pass the beet test, usually good poop, but slow transit time). c) suspected, but not a big thing for me. On the urine amino acid test (mine was all low too, despite eating a ton of meat, and ammonia was normal) aspartic acid was the only high one. Not the same as glutamate, but both excitatory...