Quote:
Originally Posted by WifeofAnt 
The main one to worry about (I had it backwards in my last post  ) is when the mother is type O. People less than type AB will eventually develop antibodies to A and/or B. Since type O women don't have either antigen they can develop antibodies to both A and B.
1/5th of all pregnancies will have an ABO incompatibility, when the baby has an antigen the mother doesn't have. Antibodies to these antigens are usually too 'big' to make their way through the placenta (type IgM). Occasionally women will also develop A and B antibodies in the IgG form which can and do cross the placenta. Fortunately less than 5% of pregnancies with ABO incompatibility develop complications (jaundice or anemia) because of it and most of them happen at birth when they're already under close supervision.
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I hadn't heard this issue with O before. Is this a problem if both parents are O, or only if the mom is O and the dad is something else? I'm O- and DH is O+ (we had him tested last time to make sure I needed to take the shot at 28 weeks). DS turned out to be my type, O-, so I didn't have to have the shot after his birth.