I immediately really liked Aniston! Yes, I soon thought of Jennifer Aniston. But SO WHAT? She's not some despicable person. She's beautiful and classy, even if she was on "Friends."
And the nonconformist in me says "who cares what everyone thinks!" That is probably why I'm naming my new dd "Marley", even though almost everyone who hears it says, "Like the movie Marley and Me?" which I've never seen and don't care about.
I do think it is more a girl's name. I disagree that a girl would have any serious "Anus-ton" problems (though a boy might). I really seriously like this name, and hate to see it shot down so quickly by everyone! But, if the majority of people react strongly against it, maybe it's not the right choice. Sigh.
Love the nickname "Ani", too!
P.S. With my first daughter, I was reading an article about Racquel Welch and her daughter was mentioned. Her name was Tahnee and I loved it! But didn't want to just copy it. So I changed it to "Tahna". Maybe you could do a variation of Aniston? Aliston? Astin? Anissa? Just an idea if you are really stuck on it.