DD is ten months old and I left her last week for four nights for a work trip. She is still BF, but wakes only once at night, and is used to taking bottles while I'm at work during the day.
I was really nervous to leave her. Other than the few hours a day I'm at work (part-time out of the house), I don't really leave her, and never overnight. But it went really well. DH and my MIL gave her all sorts of love and attention, and kept her occupied. I think it really good for both DD and grandma to have some time together.
I will say I felt very refreshed when I got back. I was able to read a whole book (!) on the flights to my meeting, took a couple long baths at the hotel room, got out to a few dinners with my co-workers, caught a show on one of our evenings off. I also got four really good nights sleep. It was really nice. Very re-charging. I spent the entire weekend after getting home just nursing, holding, and snuggling DD. I felt like I had a refilled well of patience, clearer head, and was just ready to give DD 100% of me....which was great because I was starting to feel drained before the trip.
Anyway, I think it depends on your babe and your babe.