I agree with the other posters saying to go with a name you love, regardless of letter.
I think the more children you have with the same letter, the more obligated you'll feel to have future children share that letter as well. (does that make sense?) In my opinion, having 2 children that start with "M" (for example) and a third that starts with a different letter, is not odd at all. However, having 5 children that all start with "M", and a 6th that is different seems a little more singled out, to me.
I think it really depends on the shared letter too. Whereas having a "Quinn, Quentin, Quincy, and Ava" might be a little obvious that the 4th is different...I dont think having a "Sophie, Scott, Spencer, and Lucy" is quite as much of a blaring difference since "S" is such a popular name letter.
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