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Originally Posted by Kim 
Hi all,
I am 36 (and will be at baby's birth), dh will be 34. We are very excited to meet our newest little one next year.
This time around has been different. Nausea, fatigue and cramping hit very early this time around. And some new symptoms too...dizziness and near-fainting. Woo-hoo! 
We missed the cut-off for the Quad-Screen + Nuchal Translucency test at 12 weeks. Not sure how I feel about that.
Last pregnancy we had an ultrasound and Level 2 us at 19-20 weeks that showed multiple problems -- ultimately ended up with an amniocentesis. Baby was perfect. That was a scary couple of weeks and now I'm both hesitant to be led down that road again and wanting to know (because of increased risk/age) so that I could potentially be prepared.
Anyone else doing testing? I really need to go back to the research on those tests -- risks vs. reward vs. false positive.
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I had an amnio. Risk of miscarriage was 1:1000 at my particular center. Each center has its own level of risk. It tested for down syndrome/trisomies and neural tube defects (ie. the AFP can be measured in the amniotic fluid, and is a more accurate test than the screenings that you missed). Almost impossible to have a false positive or negative, for it would only occur if there is lab error; however, lab error is fairly easy for them to detect.
I now have peace of mind that my son has no chromosomal abnormalities! Additionally, a detailed ultrasound is performed prior to the amnio, ruling out lots of anatomical abnormalities that cannot be picked up by amnio.
Since screening tests have very high false pos/neg rates, I didn't even bother. The amnio is more accurate & is a true diagnostic test (not just a "screening" test, which possibly would need to be followed up w/ a diagnostic test anyway simply b/c of my age; many older women falsely screen "positive" on a nuchal translucency scan + quad screen simply b/c our age places us in a higher risk category).
Just my choice, but I definitely understand why most choose not to do it. I debated for quite a while & read all the internet horror stories.
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