There are a variety of quilting charities, if you are into that. Linus, Project Binky, Quilts for Kids, and more I can't remember. You could also inquire of your local CASA or CPS office about making quilts for the kids that come into foster care.
A quicker small project is fleece hats, which I've done and donated to the local food pantry/clothing closet. If there's a homeless shelter nearby, you could donate there. With winter coming on, those would be welcome, I'm sure.