1-2 was much harder for me.
I had more support from family with #1 (somehow, the more kids you have, the less help they think you need, which isn't how it works!) He was a pretty mellow baby and I could take him pretty much anywhere. I didn't have to change my lifestyle at all; he was happy to sleep in until 10am or later, he liked being around people, he would happily go to work with his dad while I went to class.
Having my second was insanely difficult. My first was almost 3 and still a pretty easy guy, but taking 2 little kids anywhere is a challenge. The baby was an early bird who thought the day should start at dawn and the rest of us had a very hard adjustment to 7-8am mornings. He was and is an intense child. We adjusted, of course, and by 6 mos. it was my 3 yr. old who was giving me the most trouble but man, it wasn't easy at first.
My third is 2.5 mos. old now and adjusting to her has been a breeze! My boys are in all-day kindergarten and second grade, and they don't require the baby-type hands-on parenting (bathing, toileting, getting dressed, buckling up, etc). They help with the baby. The baby is pretty easy; she almost never cries for more than a minute and she sleeps well at night. I felt "adjusted" by the time she was a month old.