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11/30/10 at 3:49pm
Thread Starter 

I know this was briefly mentioned a while back but I got something about it in my inbox today. So the 2005 recommendation was for a single dose of conjugate vaccine in adolescence, with the assumption that duration of immunity was a good 10 years, which would get them through the peak incidence ages. Now, ACIP says they want teens to get a booster dose after 5 years. Since meningococcal meningitis is one of the diseases that terrifies people, I was wondering if anyone had any thoughts about the following points:

 

 

 

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 immunity does appear to decline after 5 years ... within a year of getting the vaccine, it's in the low 90% range ... between 2 to 5 years after vaccination, although the numbers are fairly low and the confidence intervals are wide, it looks like the protection drops into the low 50% range

 

 

  

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 some evidence for herd immunity was expected, as had been seen for the conjugate [Hib] vaccine and the conjugate pneumococcal vaccine, but that didn't appear to be happening

 

 

 

Quote:
 The vote was only 6 to 5 ... Those who opposed it saw it solely as a financial question 
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