One of my cats has asthma and is (supposed to be) taking every other day prednisone. I'm running out of tricks to get him to take it. Everything new works for a little while, then he stops taking it.
First: any solution that involves getting within ten feet of him won't work.
I'm not crazy about liquid because I won't know if he's getting all of it.
Crushing it and mixing it with food doesn't work.
I've been using pill pockets. I used to just put it in front of him, walk away, and watch while he ate it.
That stopped working-he just walked away. Then I shut him into a room until he took it (I have two other cats and one is/was getting interested in taking it herself.) That's when I started to feel like Mommie Dearest.
That stopped working. I tried not feeding him wet food (his preferred) until he took his medicine. That succeeded in him getting alarmingly skinny.
My latest was to put the pill into the pill pocket and put a tiny bit of wet food on it, put it in front of him in his favorite resting spot, and shut the door.
He can be alone with it all night and won't take it.
I'm running out of ideas. He hasn't taken his medicine in over a week. He doesn't seem distressed, but I can see he's breathing rapidly, and can also see his chest and stomach see sawing. He still runs short distances and holds his own with brief "fights" with my spunky and agressive younger kitty.