I think it depends entirely on your family, each individual child, and what you want to vaccinate against. Â For instance, if you are worried about rotovirus, there is a very limited time frame in which you can even get the vaccine, and the maximum start time, (for two or three doses) is 12 weeks of age. Â I personally believe that birth is the wrong time to give any vaccine, but considering Hep B can be easily transferred in a hospital, I imagine that is why they want to do it right after the child is born. Â (At least, I believe that's their justification for it.) Â
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My family has personally found the polio vaccine to be the safest of the required ones, so I had no problem giving that to my son mostly on schedule. Â We did, however, move to another state when DS was 6 months old, and it took until he was close to 2 years old for us to find a good pediatrician we could trust. Â We finished out the polio vaccine and worked with the pediatrician to develop another alternative schedule for him. Â My sister and I both had severe, life-threatening reactions to the old pertussis vaccine, so my husband and I had already agreed to delay and/or avoid certain vaccines based on my medical history. Â Given how things have worked with DS, I am thinking that a couple of vaccines while younger may be alright, but I prefer to wait until they are closer to 2 years old.
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Personally, I would try to stick with only one vaccine at a time, at least 30 days apart. Â That will definitely give you time to judge whether or not your children are going to have a reaction and, if they do have one, you'll know exactly which vaccine caused it.