Originally Posted by lifeguard
Part of the reason they limit it to 6 cycles is because of increased risk of cancer down the road.
You can also get hyperstimulation of the ovaries - it's rare but it's one of the reasons you should be monitored on it.
Yes, but you can get hyperstimuliation and on the 1st cycle w clomid...
2. Clomid Conception Failure: This is defined as failure to conceive after six documented ovulatory cycles on clomiphene. These patients become like any other patients with unexplained infertility and care should be taken to complete the infertility work-up if it has not been done yet including a semen analysis, HSG, post coital test, endometrial biopsy and laparoscopy to check for pelvic adhesions and or / endometriosis.
What are our opinions for these patients:
a) Low dose gonadotropin use with IUI can be considered although these patients are at risk for multiple pregnancy and OHSS.
b) IVF should be strongly considered, as this can be a diagnostic as well as a therapeutic procedure.
Clomid patients should be properly monitored to maximize the success and guard against potential side effects, including adverse affects on the cervical mucus and ovarian cyst formation. Patients should not be put on Clomid for more than 3 cycles before re-evaluating the treatment.
Clomid use for longer than 12 cycles has been associated with an increase incidence of ovarian cancer; therefore, the medication should be used judiciously and whenever the benefits outweigh the risks.
Clomid is usually successful within 3 to 4 ovulatory cycles.Use beyond this time frame is generally not recommended. As such it is extremely important for the gynecologist to be familiar with the proper indications and the limitations of this therapy.