I can also commiserate! We are moving ourselves locally - just rec'd the keys a little early a couple of days ago and will be in the new house completely by 5 March. We are military, and have moved ourselves or have had movers do it for us every 1-3 yrs for 12 yrs now, yet we still keep to collect clutter with each home (and having 3 children now is not helping lol!). I am going at it room-by-room and now that I am working on the bathroom (and going from a spacious bathroom to one with very little storage space), I am working on reducing the "stuff" in there by minimizing items, switching to simpler, more natural options our entire family can use, etc.
I am also decluttering other rooms - junkie little toys of the kids' (they are old enough to realize and to do it w/me at ages 5 and 8), going through everyone's clothes to purge the things that do not fit, going through books and DVDs, etc. Breaking it down room-by-room has helped tremendously. Also, purging items not worn, used, displayed for a year or more is helpful...as well as excessive holiday decorations (we have a ton!).
I hope your move is as stress-free as possible for you!