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I use Duozyme from Karuna and love it. I used to have horrible indigestion and haven't had any since taking it. I've even used it during pregnancy and have managed to curb most heartburn.
My nutritionist put me on it. He likes it much better than the others because it is dual stage meaning it has a gastric phase and a duodoneal phase. I've been very, very happy with it.
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This is the best site for enzyme info: http://enzymestuff.com/
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What kind/brand of enzymes kind of depends on what you need them for. Enzymedica is fabulous. I also really like Klaire Labs products. Dd used to take Houston enzymes.
We try to do lots of ferments for their enzyme activity also. No kefir because we are dairy free, but we drink kombucha with meals and eat lots of fermented veggies.
We started with Yasko's special digestive enzymes which have pancreatin (her website is holisticheal.com) and pretty soon switched over to Source Naturals Pancreatin 8x (sold places like iherb, and while they're lower dosage, that's fine for us--we don't need the dosage of Yasko's digestive enzymes).
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My son had some, um, interesting reactions to starting them (started on Yasko, switched to Source Naturals and didn't see a change or lessening of the good things), he was a bit hyperactive for a few days and his poop was forest-green, really odd, but both kids had browner, firmer poop (too loose before, or with DS it was sometimes loose, sometimes just erratic). With either, I'd start slow--my kids get vits/mins to help with the stress of making digestive changes and still my son was noticeably hyperactive. I've read that the pancreatin can (worded at my understanding level) force digestive changes faster than non-pancreatin-including digestive enzymes, but it can also suppress natural pancreatin production. I'd already started them and just stuck with them because we had a lot of things going on that were causing digestive upset. DD has stopped them and we're on to other things that I think are helping, I may start DS on them again, but they were helpful for a time.
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It's the only kind of digestive enzyme we've used, so I can't compare it to anything else.Â
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http://www.iherb.com/Source-Naturals-Pancreatin-8X-500-mg-100-Capsules/6199?at=0