I've had horrible, wake in the middle of the night thinking i'm having a panic attack, reflux since end of 1st tri. I propped myself up with a ton of pillows, but always ended up getting up in the middle of the night, chugging a glass of milk, and then dozing fitfully on the couch for 4 hrs until finally getting up, exhausted. I thought it would pass, as my leg cramps had. No such luck.
A few weeks into 2nd tri, I started having reflux during the day as well. Horrible pain! After trying milk, acv, papaya enzymes, almonds, ice cream, tums, praying to God for relief, etc, I gave in and started taking (store brand) zantac at my OB's advice. Immediate relief! Sleeping mostly through the night!
Then I got one of those squiggly 'snoodle' pregnancy pillows (second hand) and have been able to sleep through the night almost every night. I've also been able to cut back on the zantac.
I know a lot of us are wary of this kind of med, I certainly never considered taking it until my OB strongly urged me to. BUT if you are really suffering, perhaps consider it?