I got a Kindle in June. I'm not planning to stop getting regular books and only get e-books.
There really isn't anything that totally turns me off using an e-reader but a few minor things to mention.
Compared to searching for a regular book by topic or author I think the search is not as easy for e-books.
Sometimes I accidentally hit the page back button when I don't intend to.
I feel like I have to be a lot more careful because the device cost quite a bit more than an ordinary book.
I have a password to enter when I turn my device on. If I leave it on with no activity for long enough then it will go to sleep and I have to re-enter the password to continue reading.
Not everything is available as an e-book.