There are the other normal airplane and travel considerations like making sure that you get up and walk around frequently, staying hydrated, eating properly, getting enough sleep, etc. And then the fact that you'll be away from your normal care provider if anything should come up medically. So having a plan in place for how to maximize your health while traveling and what you would do (like where you would go) if you needed medical attention, would be helpful and give you peace of mind.
Also from an emotional/career standpoint I would do a bit of soul searching about how important this particular conference is to you. I know in my dh's academic field one of the major conferences is international every 4 years, but the other 3 years it is within the US. The conference is really the same, they just pick an exotic location. So he has opted not to spend the time and money on those and focus on the ones that are domestic. But if this is THE conference and you feel like it's an opportunity of a lifetime (or of your career) then it's probably really worth planning and figuring out how to make it work.