I read in Psychology Today that if you ask someone for a small favor (borrow something, catch a ride somewhere) then that person would be more likely to be your friend after that because they had already subconsciously decided that they like you when they decided to fulfill your favor request. So, that's an idea. It has worked for me somewhat.
On the rosacea, I read that taking aspirin helps. So I currently take two full-strength aspirin per day (I usually have a headache I need to kill anyway), and that has cleared up my rosacea a lot. I also take Vitamin E and Vitamin B daily because those are good for the skin, also. Also try to stay out of the sun, take not-too-hot showers, and drink lots of water.
And it sounds like you're not happy in your neighborhood. So I'd sell the house and find something smaller in a more "cozy" neighborhood. If you could find a walkable community, more people would be out and about (possibilities for friendships), and that would be good for your health. Get a dog you can take on walks and talk to other dog-walkers.