We have an 08 Sienna (also has LATCH in 4 positions) and I like it. We took out the center captain's chair in the middle row and keep it stored in the garage, it makes it easier to access the 3rd row. I have my younger two (1 year old DS2 and 3 year old DD2) in the middle row so I can snap them in. DS2 is rear-facing in a Marathon which expires in the spring and will be switched out for a RFing Radian. DD2 is currently FFing in a Radian, but has also been RFing in a Marathon in the middle row. DS1 and DD1 would just climb underneath her RFing seat and then go to the back row.
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DS1 (7) sits in the spot with no LATCH. First he was in a Radian with a seatbelt install and then early this year we moved him to a Britax Parkway SG booster. DD1 (5) is on the passenger side in the 3rd row in a Radian. DD1 can buckle herself in and DS1 can help unbuckle her. If she needs help I just reach over the middle row seat and help her snap in, I can also check to see that her straps fit properly.Â
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OK, that was too much typing, LOL, just to say that I like our Sienna. 