We largely unschool, but do have books and notebooks, magazines, art supplies, instruments, ongoing projects, and some workbooks that see use regularly. Our house is very open living, so the kitchen, living, dining, and hall are all one large space with bedrooms off to the north side. We have four tall built-in bookcases on the north side of the main living area, with a table near them. I tidy, dust, and straighten the books about once per month. We also have a re-purposed dresser nearby, painted a wonderful red, that I use to house all art supplies. It gets pretty disorderly, but at least looks nice with the drawers shut! I keep a neat stack of books and things that are used every day on that dresser. The table by the books is not used for meals, so it is "open" for the kids work all the time. Our instruments are currently on top of our buffet on the other end of the hall, but I am interested in finding better housing for them.
So, our house can appear like a tornado hit it, but usually 30 minutes of straightening up yields a tidy table-top and dresser-top, and neat bookshelves. The main work is getting all the things off the floor and doing a quick vacuum. If the floor is clean, the rest of the space feels uncluttered!!!
Now my children's bedrooms are another story . . . I choose to fight that battle once per week on Fridays.