I'm 17 weeks. I've been taking zofran since 7 weeks. I'm down to 2mg per day. I take it when I wake, every day, and I've been able to eat with a good appetite, work out, etc. At the end of the day I often feel a bit queasy and fix myself a hot chocolate or hot milk and do just fine.
Then came Sunday: up in the middle of the night several times throwing up. :( I thought maybe it was the rich food I ate (included some beef, which I rarely eat). No one else got sick and it was food that everyone ate (like, more than a dozen people). The next day I did not take the zofran and suffered from one more episode of vomiting and nausea throughout the day. I finally took the zofran in the late afternoon and by the next morning felt almost 100%.
However, since then, it seems that the nausea has escalated again. It is OK in the am and then gets worse throughout the day. If it was a food-born illness, it would be gone by now, so all I can guess is that something else is up. I'm sooooo discouraged. Just hoping I could totally quit the zofran, but if I do, I'll need full-time help again. It's terrible.