I'm using compounded progesterone suppositories 100mg, 2x/day, 81 mg aspirin/day, 4000mcg folinic/day, 1000mcg methyl B-12/day, and 50mg B-6/day.
I have a history of low progesterone.
With ds3, I used the cream but my level was never that high. Still, we had no problems.
With my 4th (loss) pregnancy, I was using the cream - but it essentially did nothing for me. My progesterone dropped on it. I used the suppositories with that pregnancy, but I started much too late. Even so, my progesterone increased pretty well on the suppositories while it had not with the cream.
I had MTHFR bloodwork done in 2006, essentially because I'm an autism mom (my oldest has autism) and autism families tend to have MTHFR mutations. I have homozygous C677T, which is the worst and linked to miscarriage. But I've never had high homocysteine, and it seems that the mutation plus high homocysteine is much more dangerous than just the mutation alone. I have never had a miscarriage prior to my 4th pregnancy, and I find that a bit puzzling. I never before have addressed my MTHFR issue in pregnancy but am for the first time - thus the above supplements.
For anyone with MTHFR, it is better to take folinic than folic - as MTHFR people don't process folic well but do absorb folinic.
I've been in conflict with whether I want to do anything further such as injections, and I think I'm deciding against it.
I'm trying very hard to be peaceful and welcoming to my baby. Its hard to not be scared, though.