I like to research. A lot. But I still have a few vaccine and VPD related questions that I can't seem to find a satisfactory answer to. I know that many of us on here have different backgrounds in research, health care, etc, and I wanted to post my queries to see if anyone knows the answer to them. Likewise, I'd like this thread to serve for others as a place to ask their random vaccine/VPD questions to others.
Vaxxers and non vaxxers alike please weigh in if you can. Just PLEASE keep it polite and civil and also PLEASE PLEASE refrain from any personal diatribes/conspiracy theories here. It is OK to post a hypothesis of why you think something might be....Just make sure it is at least based on some sort of factual research.
OK, MY questions off the top of my head are:
-Why do most CDC/department of health publications say that tetanus can be found "anywhere, even house dust" when it is proven that the spores cannot live in oxygen. An aerobic environment like house dust is fully exposed to oxygen, right?
-Why is the dose for diptheria in the DT or DTaP so much higher for children 0-7 than 7-adult? What research is there that shows that a (for example) 10 lb baby needs 7 times the dose of diptheria toxin to develop immunity than a 200 lb adult? (This also goes for pertussis, comparing the amount in the DTaP to the Tdap.)
-Why is pertussis still bundled in to the 3 part DTaP or Tdap when a full series of Tetanus and Diptheria is 3 doses followed by boosters every 10 years, and pertussis is 4 (or 5, depending on age) doses with a booster needed much more frequently? (Studies coming out say pertussis boosters might be needed every 3-5 years to maintain immunity from the primary series.) I understand why D and T would be bundled since they are on the same schedule, but why pertussis? So much extra D and T is given by combining all 3.
-Why were the strains of strep pneumonia that are in Prevnar chosen? Are they the most common strains, the most dangerous, or the ones that were more concerning at the time? Does it make sense to periodically reformulate Prevnar to reflect the current strains out there like is done with the flu vaccine?
-Are there any books out there that exist to give a factual history of the development of vaccines that are not biased either pro or anti vaccine? I have never found one myself that does not reflect the author's bias.
I have more, but let's start with these. Hope people might be able to help me answer them!