The "to get a degree or not" question I think is going to depend on so many different circumstances. If you are having trouble deciding, why don't you try submitting a resume and interviewing for positions in the fields you would like to work? That should give you a pretty clear idea of what types of classes/work you would need to do to get to where you want to be.
I think this question has a different spin when you are talking about going "back" to school to improve quality of life...if the career you ultimately want to go into requires a degree, then obviously you would need to go back to school. BUT there are ways to work your way into positions with hard work, determination, and by making connections. Just going to school to have a degree without a specific plan can be detrimental. Many places that are looking for people with a degree that isn't specialized to the field, really just want to see that there is determination and the potential for longevity. And that you mesh well with the team. My husband is a programmer and cannot find people to fill the open positions...not because people aren't "qualified" per se, but because they have sucky work ethics or can't work as part of a team...isn't that crazy in this economy?? So it's not always all about the degree, but if there is specialized knowledge needed about the field you want to be in, then it would be good to have a degree, or maybe even some specific classes would suffice.
FWIW, I have a BS degree in Molecular Biology, worked for a couple of years in the field, then became a SAHM. I still have a small amount of debt that we are paying off, but should be done soon. I have found the degree to be worth it...I worked through school and got good grades, so beyond just the degree school taught me a LOT. When, at some point I return back to work, I will probably need to take some "refresher" classes if I want to go back into the field...at the very least. If I wanted to make a career in the field, then I would need a lot more schooling. I don't think that makes my degree useless though. I'm quite sure that having it is important, and I can use it as a stepping stone into other industries.
My husband was a double major Math and Computer Science, and works in software. Again, being in school while working teaches you a lot. He has a awesome job that he finds fulfilling and he likes going to work. Definitely worth it, and still paying it off.
That being said, we made these degrees work for us. We didn't get the degrees to lean on, kwim? A degree isn't something that work's for you, it's a tool you use to get what/where you want. That's really how you need to look at it. The degree proves that you are capable of learning the information, but YOU need to prove that you are capable of actually doing the job. There is a difference there, and some people forget that. I would never recommend that someone get a degree "just because". There should be intent there.
ETA: Obviously you should take into consideration the cost of the degree vs income in the field as well.
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