One of my girlfriends mentioned her doctor offered a new test that used mom's blood, but predicted with 99% accuracy the presence of Down's and also a couple of other abnormalities. The false positive rate is much lower than the other screening tests, at 0.1%. It can be done at 10 weeks. However, apparently a lot of insurance companies don't cover it yet since it's new.
Here is an article with some info:
While I am inclined to skip all of the other testing, I might do this one...for my DH, who is worried.