Hi Taximom!
Hi Prosciencemum!
I was researching this particular web article ("30 Scientific Studies Showing the Link between Vaccines and Autism") when I stumbled across your conversation. I've spent the last few hours investigating its claims. My comments are mainly about the details in the article itself - its claims and text - but I dug deeper when it seemed to be warranted. The article contains portions of abstracts and quotes from the cited research that the article's author thought were most convincing to the anti-vaccine crowd. In most cases, further research seemed a waste of time, as you'll see.
It's much worse than Prosciencemum suspected. Only 2 of the 30 studies actually try to connect vaccines with autism in a scientific manner. If you were to decide a debate simply based on the blatant dishonesty of one side or the other ... this would rack up a lot of points for the pro-vaccine side.
Anyway, here's what I found ...
1. Hepatitis B Vaccination of Male Neonates and Autism
>>The "kids" in the study were as old as 17 at the time the study's surveys were taken (from 1997-2002). The Hepatitis B vaccine wasn't fully implemented until 1996 (according to the study's authors). Among those suffering from ADS, only 9 of 31 (29%) had been exposed to the vaccine. Autism rarely shows after age 2.
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2. Porphyrinuria in childhood autistic disorder: Implications for environmental toxicity
>>Implicates mercury from purely environmental (non-vaccine) sources.
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3. Theoretical aspects of autism: Causes—A review
>>Implicates mercury from purely environmental (non-vaccine) sources.
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4. Uncoupling of ATP-mediated Calcium Signaling and Dysregulated IL-6 Secretion in Dendritic Cells by Nanomolar Thimerosal
>>About the relationship between Thimerosal and dendritic cells - a potential sign of immune system dysregulation. No connection to autism was investigated or suggested.
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5. Gender-selective toxicity of thimerosal.
>>A study of MTD (maximum tolerable dose a.k.a. dangerous/lethal dose) of very high amounts of Thimerosal in mice and their comparative effects between male and female mice. No connection to autism was investigated or suggested.
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6. Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal
>>A study examining comparative residual effects of ethyl- vs. methylmercury doses in monkeys. Corresponding or causal effects of autism in monkeys or humans was not investigated (although strongly asserted in the report's conclusions).
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7. Increases in the number of reactive glia in the visual cortex of Macaca fascicularis following subclinical long-term methyl mercury exposure.
>>A report about very high continuous doses of methy- and ethylmercury in monkeys. No connection to autism was investigated or suggested.
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8. Neuroglial Activation and Neuroinflammation in the Brain of Patients with Autism
>>Neither vaccines nor mercury compounds are studied in this research.
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9. Autism: A Brain Disorder, or A Disorder That Affects the Brain?
>>Implicates mercury from unspecified sources.
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10. Activation of Methionine Synthase by Insulin-like Growth Factor-1 and Dopamine: a Target for Neurodevelopmental Toxins and Thimerosal
>>Implicates ethanol, lead, mercury, and aluminum as possible inhibitors of methylation. No connection to autism was investigated or suggested.
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11. Validation of the Phenomenon of Autistic Regression Using Home Videotapes
>>Neither vaccines nor mercury compounds are studied in this research.
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12. Blood Levels of Mercury Are Related to Diagnosis of Autism: A Reanalysis of an Important Data Set
>>A review of another study, challenging its analysis of levels of mercury from unspecified sources in ADS persons.
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13. Developmental Regression and Mitochondrial Dysfunction in a Child With Autism
>>No mercury compounds are studied in this research. Implicates both infections and immunizations as agents of mitochondrial dysfunction. A connection with autism is suggested but not investigated.
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14. Oxidative Stress in Autism: Elevated Cerebellar 3-nitrotyrosine Levels
>>Implicates mercury from unspecified sources.
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15. Large Brains in Autism: The Challenge of Pervasive Abnormality
>>Implicates heavy metals, but not specifically mercury, from unspecified sources.
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16. Evidence of Toxicity, Oxidative Stress, and Neuronal Insult in Autism
>>Implicates unspecified toxins and "oxidative stress and neuronal insult", but not specifically mercury, from unspecified sources.
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17. Oxidative Stress in Autism
>>Implicates "oxidative stress", but not specifically mercury, from unspecified sources.
>>(Same "researchers" as in #16.)
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18. Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors
>>Implicates oxidants as a cause of glutathione depletion. A connection to autism was suggested but not investigated.
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19. Aluminum adjuvant linked to gulf war illness induces motor neuron death in mice
>>Neither mercury nor autism are addressed in this research.
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20. Environmental mercury release, special education rates, and autism disorder: an ecological study of Texa
>>Implicates mercury from purely environmental (non-vaccine) sources.
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21. Autism Spectrum Disorders in Relation to Distribution of Hazardous Air Pollutants in the SF Bay Area
>>Implicates heavy metals, mercury, cadmium, nickel, trichloroethylene, and vinyl chloride from unspecified sources.
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22. A Case Series of Children with Apparent Mercury Toxic Encephalopathies Manifesting with Clinical Symptoms of Regressive Autistic Disorder
>>Implicates mercury from unspecified sources. No connection to autism was investigated.
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23. Attention-deficit hyperactivity disorder and blood mercury level: a case-control study in chinese children
>>Implicates mercury from unspecified sources. "Whether the relationship is causal requires further studies.” No connection to autism was investigated or suggested.
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24. The Changing Prevalence of Autism In California
>>No vaccines or mercury compounds are studied in this research. It challenges the idea that increasing diagnoses of ADS are due to diagnostic substitution.
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25. Mitochondrial Energy-Deficient Endophenotype in Autism
>>No vaccines or mercury compounds are studied in this research.
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26. Bridging from Cells to Cognition in Autism Pathophysiology: Biological
>>No vaccines or mercury compounds are studied in this research.
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27. Heavy-Metal Toxicity—With Emphasis on Mercury
No specific connection with ADS is considered in this research.
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28. Evidence of Mitochondrial Dysfunction in Autism and Implications for Treatment
>>No vaccines or mercury compounds are studied in this research.
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29. Proximity to point sources of environmental mercury release as a predictor of autism prevalence
>>Implicates mercury from unspecified sources. "Nothing is known about specific exposure routes, dosage, timing, and individual susceptibility."
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30. Epidemiology of autism spectrum disorder in Portugal: prevalence, clinical characterization, and medical conditions
>>No vaccines or mercury compounds are studied in this research.
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