Hyperemisis is miserable! The poor woman.
Zofran is a very safe medication, in fact much safer than continued vomiting or avoiding food or dehydrating continually. It allows the mother to continue eating and remain hydrated, which is much safer for the baby than the nausea and vomiting. I would support her as you can, without giving advice, and if she didn't ask for herbal suggestions, support her in taking the Zofran. I had hyperemeis during my last pregnancy, due to chronic migraine, and none of the herbal or homeopathic remedies worked. I dreaded moving, especially if I was lying down, and spent much time in my first trimester lying around, only to have to go on bedrest during my second and third trimester. It was not a pleasant pregnancy by any stretch. I had to resort to Compazine and wish I had been given Zofran (it was new then and I didn't know about it) as it doesn't cause anxiety as Compazine can. I took as little as I could to get by, but I told no one I was taking it... mainly because I didn't want any suggestions on what might be "more natural." The medication worked and I didn't have the strength to defend my choices at that point.