We've had a number of sleeping arrangements between both kids and through the years, but we would either use the guest room for romance, and in fact sometimes my husband was sleeping in there full time depending on how much sleep he'd get in the family bed and his work situation and how much he needed the sleep. That didn't hurt our sex life either.
After one of my kids, my hormones took a nose dive and I had no interest in sex at all for a while, and in fact was even a bit repulsed by the idea of being touched. However, my hormones went back to normal during the co-sleeping period and our sex life returned to normal as well with no changes to who slept where. So hormones can screw up a sex life as I've seen. But I think if the hormones are there, the sex will be there as well.