I can't answer for the OP but my mum homeschooled me while working fulltime too. In our case it was fairly easy because she either worked for family and was able to bring me with her or later had her own business with my stepdad, so again could bring me with her. She used a self-paced workbook system so I really did alot of the learning on my own, but it worked well for us.
I am homeschooling my ds now, but just barely working from home at this point (though I did just talk to a mama in my area about some job opportunities where the kiddos would be able to be with me most of the time

I think I learned the multi-tasking part of it from my mom though....listen to ds read while I am doing something else etc.