From the reply which was shared here:
“We believe that the vaccines required for children are safe. The claims of a link between the MMR vaccine or the thimerosal in vaccines and autism have been extensively investigated and discounted by competent scientists….
For scientific information about vaccine safety, you can go on the internet to the Immunization Safety Review by the Institute of Medicine”
Okay, let’s look at some of what the IOM has had to say recently on the subject of vaccine safety: (you might wish to share some or all of this with the person who emailed you, and ask if she has anything she can directly cite from the IOM which contradicts these findings/more recent conclusions.)
BTW, If anyone here has anything more recently issued from the IOM which revises or contradicts these findings, I would be very interested in seeing it. Thanks!
Please note:
The IOM reviews the available research in reaching its findings.
To avoid any conflict of interest, that panel specifically excludes "anyone who had participated in research on vaccine safety, received funding from vaccine manufacturers or their parent companies, or served on Vaccine Advisory Committees." This in stark contrast to some other “vaccine advocacy groups” like the CDC, to name but one, in which the web of conflicting interests is quite tangled.
The most frequently recurring “finding” of the IOM over the years has been that they consider themselves unable to reach a finding on the issue before it, due to “inadequate” (both in terms of quantity and quality) data. Virtually every report concludes with a call for more and better conducted research into the issue.
The autism issue, specifically, has NOT been “disproved” to date, and in fact, there is much evidence supporting an association.
http://books.nap.edu/books/030904895....html#page_top
“In the course of its review, the committee encountered many gaps and limitations in knowledge bearing directly or indirectly on the safety of vaccines. These include inadequate understanding of the biological mechanisms underlying adverse events following natural infection or immunization, insufficient or inconsistent information from case reports and case series, inadequate size or length of follow-up of many population-based epidemiologic studies, and limited capacity of existing surveillance systems of vaccine injury to provide persuasive evidence of causation.
The committee found few experimental studies published in relation to the number of epidemiologic studies published. Clearly, if research capacity and accomplishment in these areas are not improved, future reviews of vaccine safety will be similarly handicapped.”
http://www.909shot.com/PressReleases...2iomreport.htm
“For Immediate Release
February 20, 2002
IOM REPORT ON CHILD VACCINATIONS URGES MORE RESEARCH
The report, issued by the IOM’s Immunization Safety Review Committee, found that scientific evidence from epidemiological studies on whether allergy, including asthma, can be caused by multiple vaccinations was conflicting and concluded that the evidence “was inadequate to accept or reject a causal relationship.” The Committee concluded that epidemiological studies to date “favor rejection of a causal relationship between multiple immunizations and increased risk for infections and for type 1 diabetes.” However, the Committee also concluded that they did find some biological mechanism evidence that vaccines could increase the risk of immune dysfunction in some children that could lead to increased infections and allergy, including asthma. They stated that “the biological mechanisms evidence regarding increased risk for infections is strong.” …The National Vaccine Information Center (NVIC) has long advocated increased basic science research into the biological mechanisms for immunity and vaccine adverse events, with particular emphasis on identifying genetic and other biomarkers that may play a role in increasing susceptibility for vaccine-induced neuroimmune dysfunction. Acknowledging the absence of research into this area, the Committee said, “The Committee was unable to address the concern that repeated exposure of a susceptible child to multiple immunizations over the developmental period may also produce atypical or non-specific immune or nervous system injury that could lead to severe disability or death. (Fisher, 2001). There are no epidemiological studies that address this. Thus, the committee recognizes with some discomfort that this report addresses only part of the overall set of concerns of some of those most wary about the safety of childhood immunizations.” ….
>>>IOM Report Reveals Lack Of Adequate Scientific Studies - In Adverse Events Associated with Childhood Vaccines published in 1994 by the Institute of Medicine, National Academy of Sciences, observations about the limitations of hepatitis B vaccine studies included the statements that "it is important to note that individual trials usually involved a few hundred subjects for study...when larger vaccination programs were monitored, observations of adverse events were necessarily less detailed and less accurately reported" and "the studies were not designed to assess serious, rare adverse events; the total number of recipients is too small and the follow-up generally too short to detect rare or delayed serious adverse reactions."
The IOM report also noted that no controlled observational studies or controlled clinical trials have ever been held to evaluate repeated reports that hepatitis B vaccine can cause Guillain-Barre syndrome; arthritis; transverse myelitis, optic neuritis, multiple sclerosis and other central demyelinating diseases of the nervous system (degeneration of the myelin sheath of the brain that helps transmit nerve impulses); or sudden infant death syndrome (SIDS).
A major conclusion of the Institute of Medicine report was that almost no basic science research has been undertaken to define at the cellular and molecular level the biological mechanism of vaccine-induced injury and death. The report concluded that "The lack of adequate data regarding many of the adverse events under study was of major concern to the committee...the committee encountered many gaps and limitations in knowledge bearing directly or indirectly on the safety of vaccines. These include inadequate understanding of the biologic mechanisms underlying adverse events following natural infection or immunization, insufficient or inconsistent information from case reports and case series...and inadequate size or length of follow-up of many population-based epidemiologic studies…."
Re’ Autism:
http://www.iom.edu/includes/DBFile.asp?id=4132
“The evidence favors a rejection of a causal relationship at the population level…Moreover, the committee can find no proven biological mechanisms that would explain such a relationship (citing the plausibility of as association and the difficulties inherent in animal models and human case studies in demonstrating any such biological mechanism.)….Though the MMR-autism question might appear to be resolved, science is always a work in progress; a conclusion is only as good as the methods of the analysis. The epidemiological studies, traditional public health tools used to examine the risk factors for a disease on a population level, were at a disadvantage here because there is little variation in exposure to MMR, since children in most developed countries are vaccinated similarly (lack of a control group, often cited as a hindrance to meaningful research/conclusions) Furthermore, the difficulties in diagnosing and determining the exact onset of autism in children make it difficult to design appropriate studies and compare the results…The committee could not rule out another possibility- that MMR vaccine could contribute to ASD in a small number of children…(the available tools being inadequate to detect the association).”
Re’ thimerosal:
http://www.iom.edu/report.asp?id=4717
“Current scientific evidence neither proves nor disproves a link between the mercury-containing preservative thimerosal and neurodevelopmental disorders in children, says a new report from the Institute of Medicine of the National Academies…
The committee's comprehensive assessment of the scientific literature on thimerosal included analyses of published and unpublished studies proposing an association with disorders such as autism, and it found them to be inconclusive. “
http://www.iom.edu/includes/DBFile.asp?id=4134
“The committee finds that the hypothesized association between thimerosal containing vaccines and neurodevelopment disorders rests on indirect and incomplete information…however, data on mercury toxicity more generally suggests that the hypothesis is biologically plausible.”
Re’ SIDS:
http://www.iom.edu/report.asp?id=5391
“The evidence regarding biological mechanisms is essentially theoretical, reflecting in large measure the lack of knowledge concerning the pathogenesis of SIDS. Anaphylaxis related to vaccination has been discussed in detail in previous IOM reports and is reexamined in the report; the committee observed that anaphylaxis is known to be a rare but causally related adverse event following the administration of some vaccines. Fatal anaphylaxis in infants is extraordinarily rare. The committee found no basis for a review of current immunization policies, but saw a clear need for continued research on adverse event following vaccination and on the biological basis for sudden unexpected infant deaths.”
Re’ Demyelinating disorders:
http://www.iom.edu/report.asp?id=4435
“Evidence of possible biological mechanisms that could produce this effect was weak. Additionally, the committee found that the epidemiological evidence favors rejection of a causal relationship between the hepatitis B vaccine in adults and multiple sclerosis.
However, the evidence was inadequate to accept or reject a causal relationship between the hepatitis B vaccine and all other demyelinating conditions.
Because of the lack of epidemiological data on conditions other than MS in adults, the committee recommends further attention in the form of research and communication”
http://books.nap.edu/nap-cgi/morehit...file=17-90.htm
“When an infectious agent has been associated with a particular adverse health outcome, the possibility exists that a vaccine against that agent could have a similar effect. The primary effect of HBV infection is hepatic, but occasional extrahepatic manifestations occur, such as rash, arthritis, and arthralgias. Central or peripheral neurological manifestations are not a prominent feature of HBV infection, but anecdotal reports in review articles mention an association between acute infection and MS.”
Re’ Guillain-Barre, specifically:
http://www.iom.edu/report.asp?id=4435
“ It is well established, for example…that some influenza vaccines have been associated with a risk of Guillain-Barre syndrome…”
“Guillain-Barre Syndrome GBS is the most common acquired peripheral demyelinating disease in humans (Waubant and Stuve, 2002~. Its incidence is estimated at 1 to 2 cases per 100,000 population per year both in children and adults (IOM, 1994~.
Despite the limitations of case reports, the causality argument for at least one vaccine-related adverse event (the relationship between vaccines containing tetanus toxoid and Guillain-Barre syndrome) was strengthened most by a single, well-documented case report on recurrence of the adverse event following re-administration of the vaccine, a situation referred to as a "rechallenge" “
http://books.nap.edu/nap-cgi/morehit...file=48-98.htm
“A causal relationship between a vaccine and an autoimmune disorder was found for MMR and thrombocytopenia, OPV and Guillain-Barre Syndrome (GBS), and tetanuscontaining vaccines and GBS. In addition, some types of influenza vaccine are associated with GBS and rubella with arthritis. Vaccinia is associated with acute disseminated encephalomyelitis.
Re’ allergic disorders incl. Asthma:
http://www.iom.edu/report.asp?id=4432
"(The Committee)found that epidemiological evidence regarding risk for allergic disease, particularly asthma, was inadequate to accept or reject a causal relationship. “
Re’ arthritis, specifically:
http://aafp.org/afp/970201ap/special1.html
“MMR:
Evidence favored acceptance of a casual relationship: Chronic arthritis
Evidence established a casual relationship: Acute arthritis”
Re’ SV40/cancer/polio vaccine:
http://www.iom.edu/report.asp?id=4317
“Although SV40 has biological properties consistent with a cancer-causing virus, it has not been conclusively established whether it might have caused cancer in humans. Studies of groups of people who received polio vaccine during 1955-1963 provide evidence of no increased cancer risk.
However, because these epidemiologic studies are sufficiently flawed, the committee concluded in this report that the evidence was inadequate to conclude whether or not the contaminated polio vaccine caused cancer. In light of the biological evidence supporting the theory that SV40-contamination of polio vaccines could contribute to human cancers, the committee recommends continued public health attention in the form of policy analysis, communication, and targeted biological research.”
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