Well, I've been on St. Johns for 4 months now, and MOST of the time it seems to be helpful. It is classified as a mild SSRI. It's considered safe while breastfeeding (at least by my CNMs, one of which is a lact. conslt), but not during pregnancy because of it's effects on the uterus, I think. I'm browsing this forum today because I think the St. Johns is just not cutting it anymore. I'm having to work really hard to keep my temper. It has helped a lot w/ my anxiety and insomnia, but I still have almost zero motivation and feel pretty irritable most of the time. My CNM said if it ever stops working to call her and she'd prescribe something. Ofcourse when I saw her I was feeling great. So, just have to make the call.
The thing about S.J's is you have to take it 3 times a day and you can't forget, or else its effect seems to be inconsistent. It also takes a few days at first to build in your system and to see results.
HTH